MEIS1 and EMX2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		MEIS1	EMX2
Description		Meis homeobox 1	empty spiracles homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Eye Development Lens Morphogenesis In Camera-type Eye Regulation Of Transcription By RNA Polymerase II Brain Development Locomotory Behavior Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Animal Organ Morphogenesis Hemopoiesis Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis	Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Response To Xenobiotic Stimulus Anterior/posterior Pattern Specification Dentate Gyrus Development Cerebral Cortex Regionalization Cell Proliferation In Forebrain Forebrain Cell Migration Neuron Differentiation Ureter Morphogenesis
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 28334814) Apolipoprotein A1 levels ( 32203549) Chronotype ( 30696823) Coffee consumption ( 31046077) Colorectal cancer (diet interaction) ( 24743840) Early spontaneous preterm birth ( 31194736) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Endometriosis ( 27506219) Glaucoma (primary open-angle) ( 29891935) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Insomnia ( 27992416 32332799) Insomnia complaints ( 28604731) Insomnia complaints (continuous) ( 28604731) Insomnia complaints (dichotomous) ( 28604731) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intraocular pressure ( 29785010) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Morning person ( 30696823) Photic sneeze reflex ( 27182965) Platelet count ( 32888494) PR interval ( 30679814 30046033 32439900 20062060 23139255 21347284) PR segment duration ( 24850809) Relative amplitude of rest-activity cycles ( 30120083) Resting heart rate ( 27798624) Restless legs syndrome ( 17637780 33239738 29029846 21779176) Sleep activity levels ( 33075057) Sleep duration ( 30531941) Sleep start time ( 33075057) Sleep traits (multi-trait analysis) ( 27992416) Systolic blood pressure ( 30224653 30578418) Triglycerides ( 30275531) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Airflow obstruction ( 22837378) Celiac disease ( 23936387) Chronotype ( 30696823) Double-edged eyelids ( 29895819) Early cardiac repolarization ( 22683750) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Liver fibrosis (total hepatic collagen content) ( 32953199) Low tan response ( 29739929) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Pulmonary function in asthmatics ( 23541324) Response to quetiapine in schizophrenia ( 29503163) Serum uric acid levels ( 30993211 29403010) Skin pigmentation ( 30664655) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Urate levels ( 31578528)
Interacting Genes		27 interacting genes: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B	5 interacting genes: EIF4E GTF2A1L MEIS1 OTUD6A TLE2
Entrez ID		4211	2018
HPRD ID		03442	02495
Ensembl ID		ENSG00000143995	ENSG00000170370
Uniprot IDs		O00470	Q04743
PDB IDs		4XRS 5EGO
Enriched GO Terms of Interacting Partners?
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