MEFV and ULK1

Number of citations of the paper that reports this interaction (PubMedID 26347139)
104

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MEFV	ULK1
Description		MEFV innate immuity regulator, pyrin	unc-51 like autophagy activating kinase 1
Image
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Microtubule Microtubule Associated Complex Lamellipodium Cytoplasmic Vesicle	Cytoplasm Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Membrane Cytosol Axon Phagophore Assembly Site Membrane Recycling Endosome Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Phagophore Assembly Site Membrane Extrinsic Component Of Autophagosome Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding GTPase Binding Protein Serine Kinase Activity
	Biological Process	Inflammatory Response Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Response To Interferon-gamma Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Pyroptosome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity	Autophagosome Assembly Autophagy Of Mitochondrion Protein Phosphorylation Autophagy Signal Transduction Protein Localization Positive Regulation Of Autophagy Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels Piecemeal Microautophagy Of The Nucleus Response To Starvation Late Nucleophagy Protein Autophosphorylation Negative Regulation Of Collateral Sprouting Axon Extension Reticulophagy Positive Regulation By Symbiont Of Host Autophagy Positive Regulation Of Autophagosome Assembly
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	Macroautophagy TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs Receptor Mediated Mitophagy
Drugs			Fostamatinib
Diseases
GWAS		Ankylosing spondylitis ( 30946743)	Body mass index ( 26426971) Mercury levels ( 26025379)
Interacting Genes		12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1	21 interacting genes: ATG9A BECN1 EXOC8 GABARAP GABARAPL1 GABARAPL2 MAPK14 MBP MEFV MUL1 NEDD4L OCLN POLE PPP1CA PRKAA1 SDCBP SMCR8 STAMBP SYNGAP1 UBC USP20
Entrez ID		4210	8408
HPRD ID		02012	11933
Ensembl ID		ENSG00000103313	ENSG00000177169
Uniprot IDs		D2DTW2 O15553	O75385
PDB IDs		2MPC 2WL1 4CG4	4WNO 4WNP 5CI7 6HYO 6MNH 6QAS
Enriched GO Terms of Interacting Partners?
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