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MEF2C and HDAC5
Number of citations of the paper that reports this interaction (PubMedID
10737771
)
187
Data Source:
HPRD
(in vitro)
MEF2C
HDAC5
Description
myocyte enhancer factor 2C
histone deacetylase 5
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Sarcoplasm
Nuclear Speck
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Postsynapse
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Nuclear Speck
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Minor Groove Of Adenine-thymine-rich DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Histone Deacetylase Binding
Protein Heterodimerization Activity
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Histone Deacetylase Activity
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Identical Protein Binding
Histone Deacetylase Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Blood Vessel Development
Osteoblast Differentiation
Neuron Migration
B Cell Homeostasis
Heart Looping
Endochondral Ossification
Blood Vessel Remodeling
Chondrocyte Differentiation
Germinal Center Formation
Regulation Of Germinal Center Formation
Primary Heart Field Specification
Secondary Heart Field Specification
Outflow Tract Morphogenesis
Sinoatrial Valve Morphogenesis
Cardiac Ventricle Formation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Humoral Immune Response
Nervous System Development
Heart Development
Muscle Organ Development
Skeletal Muscle Tissue Development
Muscle Cell Fate Determination
Learning Or Memory
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Alkaline Phosphatase Activity
Neural Crest Cell Differentiation
Myotube Differentiation
Cell Differentiation
Neuron Differentiation
Platelet Formation
Negative Regulation Of Ossification
Melanocyte Differentiation
Positive Regulation Of Bone Mineralization
Positive Regulation Of B Cell Proliferation
Cellular Response To Trichostatin A
B Cell Proliferation
Regulation Of Neuron Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Myoblast Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Neurotransmitter Secretion
Regulation Of Synaptic Plasticity
Positive Regulation Of Skeletal Muscle Tissue Development
Neuron Development
Cell Morphogenesis Involved In Neuron Differentiation
B Cell Receptor Signaling Pathway
Smooth Muscle Cell Differentiation
Regulation Of Synapse Assembly
Regulation Of Synaptic Transmission, Glutamatergic
Ventricular Cardiac Muscle Cell Differentiation
Regulation Of Synaptic Activity
Positive Regulation Of Cardiac Muscle Cell Proliferation
Excitatory Postsynaptic Potential
Regulation Of Dendritic Spine Development
Renal Tubule Morphogenesis
Cellular Response To Lipopolysaccharide
Cellular Response To Calcium Ion
Cellular Response To Parathyroid Hormone Stimulus
Cellular Response To Xenobiotic Stimulus
Cellular Response To Fluid Shear Stress
Cellular Response To Transforming Growth Factor Beta Stimulus
Glomerulus Morphogenesis
Nephron Tubule Epithelial Cell Differentiation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Macrophage Apoptotic Process
Regulation Of NMDA Receptor Activity
Regulation Of AMPA Receptor Activity
Positive Regulation Of Cardiac Muscle Cell Differentiation
Positive Regulation Of Behavioral Fear Response
Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis
Positive Regulation Of Skeletal Muscle Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Chromatin Remodeling
Protein Deacetylation
Inflammatory Response
Regulation Of Myotube Differentiation
Negative Regulation Of Myotube Differentiation
Histone Deacetylation
B Cell Differentiation
Cellular Response To Insulin Stimulus
Regulation Of Gene Expression, Epigenetic
B Cell Activation
Regulation Of Protein Binding
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Histone H3 Deacetylation
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Histone H3-K9 Acetylation
Pathways
ERK/MAPK targets
Transcriptional activation of mitochondrial biogenesis
Circadian Clock
Myogenesis
MECP2 regulates transcription factors
Heme signaling
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
Regulation of PTEN gene transcription
Drugs
Belinostat
Panobinostat
Diseases
GWAS
Accelerometer-based physical activity measurement (average acceleration) (
29899525
)
Adult body size (
32376654
)
Alcohol consumption (
31358974
)
Alcohol consumption (drinks per week) (
30643258
)
Alzheimer's disease (
31473137
)
Alzheimer's disease (late onset) (
24162737
)
Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) (
31835028
)
Attention deficit hyperactivity disorder (
29325848
)
Bipolar disorder lithium response (categorical) or schizophrenia (
29121268
)
Body mass index (
26426971
)
Bone mineral density (
21533022
24249740
23572186
)
Bone mineral density (hip) (
19801982
)
Bone mineral density (total hip) (
29883787
)
Bone mineral density (Ward's triangle area) (
27397699
)
Caffeine consumption from coffee (
33287642
)
Chronotype (
30696823
)
Cognitive ability (
29186694
)
Cognitive ability (MTAG) (
29186694
)
Depression (
29700475
)
Femoral neck bone mineral density (
29499414
32239398
22504420
)
Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass (
32239398
)
General cognitive ability (
29844566
)
Glomerular filtration rate in chronic kidney disease (
26420894
)
Height (
20881960
25282103
25429064
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Household income (MTAG) (
31844048
)
Intelligence (
28530673
)
Intelligence (MTAG) (
29326435
)
Lamb consumption (
32066663
)
Lymphocyte percentage of white cells (
32888494
)
Major depressive disorder (
27479909
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean platelet volume (
22139419
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Morning person (
30696823
)
Multiple sclerosis (
31604244
)
Number of sexual partners (
30643258
)
Photic sneeze reflex (
27182965
)
Platelet count (
22139419
32888494
27863252
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Red blood cell count (
32888494
27863252
)
Refractive error (
32231278
)
Regular attendance at a religious group (
29970889
)
Retinal arteriolar caliber (
23776548
)
Retinal vascular caliber (
21060863
)
Rosacea symptom severity (
29771307
)
Schizophrenia (
25056061
30285260
)
Serum alkaline phosphatase levels (
33547301
)
Smoking status (ever vs never smokers) (
30643258
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Tonometry (
17903302
)
Vascular endothelial growth factor levels (
26910538
)
Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) (
28448500
)
Waist circumference adjusted for BMI in active individuals (
28448500
)
Waist circumference adjusted for body mass index (
28448500
)
Apolipoprotein A1 levels (
32203549
)
Bipolar disorder (
33263727
31043756
)
Bone mineral density (hip) (
19801982
)
Bone mineral density (spine) (
19801982
)
HDL cholesterol levels (
32203549
)
Heel bone mineral density (
30598549
28869591
)
Mean platelet volume (
32888494
)
Interacting Genes
36 interacting genes:
ASCL1
CCNB1
CDK1
COPS5
COX7C
CSNK2A1
EDIL3
EP300
EPAS1
GATA4
HDAC4
HDAC5
HDAC7
HDAC9
MAPK14
MAPK7
MEF2D
MYOD1
MYOG
NCOA2
NOTCH1
NR2F1
PLA2G12A
SEC23A
SMAD2
SOX18
SP1
SPTBN1
TEAD1
TICAM2
TWIST2
UBE2I
VGLL2
VGLL4
YWHAZ
ZFYVE16
69 interacting genes:
ADGRB2
ANKRA2
ANKRD11
ATF3
BCL6
BCOR
BRMS1
CAMK1
CAMTA2
CBX5
CIITA
CTBP1
DDX20
DYRK1B
EEF1G
ESR1
GABARAP
GATA1
GATA2
GCM1
GNB1
GOSR2
H3C1
HDAC3
HDAC7
HIF1A
HOXC11
HR
JDP2
KLF4
LMO2
MAFF
MEF2A
MEF2C
MEF2D
NCOR1
NCOR2
NFATC1
NFKB2
NFKBIE
NRIP1
PHB2
PKN1
PKN2
PRKAA1
PRKCD
PRKD1
PSME3
RFXANK
RUNX3
SFN
SGCA
SIK1
SIK2
SIK3
SLC2A4RG
SMAD3
SPARC
ST3GAL3
SUV39H1
TAB2
UBC
UBE2I
UTP18
VAT1
YWHAB
YWHAE
YWHAQ
ZBTB16
Entrez ID
4208
10014
HPRD ID
02809
09246
Ensembl ID
ENSG00000081189
ENSG00000108840
Uniprot IDs
A0A024RAL6
A0A024RAL7
A0A0D9SGI5
D8L7E9
Q06413
Q9UQL6
PDB IDs
5UWI
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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