MCM7 and CEP68

Number of citations of the paper that reports this interaction (PubMedID 28578000)
2

Data Source:
BioGRID (pull down)

		MCM7	CEP68
Description		minichromosome maintenance complex component 7	centrosomal protein 68
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nucleolus Cytosol Membrane MCM Complex CMG Complex	Nucleoplasm Centrosome Cytosol Cell Junction Centriolar Satellite
	Molecular Function	DNA Binding DNA Helicase Activity Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity	Protein Binding Protein Kinase Binding Protein Domain Specific Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus	Centrosome Cycle Centriole-centriole Cohesion Protein Localization To Organelle
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 28416818 28416822 30061737 29892015) HDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Platelet distribution width ( 32888494) Pulse pressure ( 28135244 27841878 30578418) Systolic blood pressure ( 27841878 30578418) Triglyceride levels ( 32203549) Triglycerides ( 30275531 25961943) Type 2 diabetes ( 30054458 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		78 interacting genes: ABI2 AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC42 CDC45 CDC6 CDC7 CDK7 CDKN1B CEP68 CHEK1 COG6 CRLS1 DBF4 DNAAF6 DUX4 DYNC1I1 ELOC ESCO2 FHL2 GOLGA2 H3-4 HIF1A IKBKG IKZF3 INTS6 KIFC3 LINC01554 LNX2 MAGEA6 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MCMBP MEOX2 MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RBPMS RINT1 RPA1 SMC1A SNTA1 SP2 SSX2IP TFIP11 TREX1 TRIM27 TRIM54 TRIM55 TRIM63 UBE3A UBQLN1 USHBP1	13 interacting genes: AAK1 COG2 CTBP1 CTBP2 HGS LGALSL MCM7 SERTAD2 SNRNP27 TRAF3IP3 TRIM54 TSNAX USHBP1
Entrez ID		4176	23177
HPRD ID		01154	13808
Ensembl ID		ENSG00000166508	ENSG00000011523
Uniprot IDs		A0A0S2Z4A5 C6EMX8 P33993	Q76N32
PDB IDs		6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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