MCM2 and CDT1

Number of citations of the paper that reports this interaction (PubMedID 21930785)
29

Data Source:
BioGRID (pull down)

		MCM2	CDT1
Description		minichromosome maintenance complex component 2	chromatin licensing and DNA replication factor 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm MCM Complex CMG Complex	Kinetochore Nucleus Nucleoplasm Cytosol Nuclear Body
	Molecular Function	DNA Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding Histone Binding 3'-5' DNA Helicase Activity Metal Ion Binding	DNA Binding Chromatin Binding Protein Binding DNA Polymerase Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Nucleosome Assembly Apoptotic Process Cellular Response To Interleukin-4 Cochlea Development Mitotic DNA Replication Initiation Negative Regulation Of DNA Helicase Activity	DNA Replication Checkpoint Signaling Mitotic Cell Cycle Chromosome Segregation Regulation Of DNA-dependent DNA Replication Initiation Positive Regulation Of Protein-containing Complex Assembly Regulation Of Chromosome Organization Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Positive Regulation Of DNA Replication Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization DNA Replication Preinitiation Complex Assembly Response To Sorbitol Deactivation Of Mitotic Spindle Assembly Checkpoint Regulation Of DNA Replication Origin Binding Negative Regulation Of Protein Localization To Kinetochore Positive Regulation Of Protein Localization To Kinetochore Positive Regulation Of DNA-dependent DNA Replication
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Red cell distribution width ( 32888494) Refractive error ( 32231278)	Glycated hemoglobin levels ( 28898252) Hair color ( 26926045) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010 20139978 28017375) Mean corpuscular volume ( 29403010)
Interacting Genes		58 interacting genes: AKAP8 APP ASF1A ATM ATR CCNB2 CCNC CD86 CDC45 CDC6 CDC7 CDK2 CDK4 CDK6 CDKN2A CDT1 CPSF1 CSNK2A1 DBF4 ELL EP300 ESCO2 FBXO7 GINS4 GNB5 GTF2B GTF2H1 H3-4 KAT7 MCM10 MCM3 MCM4 MCM5 MCM6 MCM7 MCPH1 MOB4 MPP3 ORC1 ORC2 ORC4 ORC5 ORC6 P2RX4 PHB PHC2 PLK1 PTEN RAD52 RPA1 RPA2 RPA3 RPS4X SIK1 TBP TCEA2 TERF1 TERF2IP	29 interacting genes: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 COL6A3 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK14 MCM2 MCM4 MCM6 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB
Entrez ID		4171	81620
HPRD ID		00303	06900
Ensembl ID		ENSG00000073111	ENSG00000167513
Uniprot IDs		P49736	Q9H211
PDB IDs		4UUZ 5BNV 5BNX 5BO0 5C3I 5JA4 6XTX 6XTY 6YA7	2LE8 2WVR 6QCG
Enriched GO Terms of Interacting Partners?
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