MBP and TRPM7

Number of citations of the paper that reports this interaction (PubMedID 14594813)
61

Data Source:
HPRD (in vitro)

		MBP	TRPM7
Description		myelin basic protein	transient receptor potential cation channel subfamily M member 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cell Surface Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery	Ruffle Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protease Binding Protein Binding Calmodulin Binding Structural Constituent Of Myelin Sheath	Actin Binding Cation Channel Activity Calcium Channel Activity ATP Binding Myosin Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Positive Regulation Of Interleukin-6 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Calcium Ion Transport Cellular Magnesium Ion Homeostasis Calcium-dependent Cell-matrix Adhesion Actomyosin Structure Organization Protein Autophosphorylation Protein Tetramerization Necroptotic Process Calcium Ion Transmembrane Transport Divalent Inorganic Cation Homeostasis Cation Transmembrane Transport
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	TRP channels
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester 1,4-Dithiothreitol
Diseases
GWAS		Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Calcium levels ( 29403010) Chronic obstructive pulmonary disease ( 30804561) Electrocardiographic traits (multivariate) ( 32602732) Household income (MTAG) ( 31844048) Pulse pressure ( 27841878) QT interval ( 24952745) Systolic blood pressure ( 27841878)
Interacting Genes		82 interacting genes: ABL1 ADRB2 APTX ATN1 ATXN1 AURKA BMP2K CCR1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 CTDSPL DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP2K1 MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEK9 PAK1 PDGFRL PKN1 PLEKHF2 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTAFR PTPRA RAF1 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSC1 TSSK6 ULK1	9 interacting genes: ANXA1 EEF2 H3-4 MBP PLCB1 PLCB2 PLCB3 PLCG1 TRPM6
Entrez ID		4155	54822
HPRD ID		01158	10418
Ensembl ID		ENSG00000197971	ENSG00000092439
Uniprot IDs		A0A024R384 P02686	A0A024R5V1 H0YLN8 Q96QT4
PDB IDs		1BX2 1FV1 1HQR 1K2D 1QCL 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?
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