MARS1 and CYP27B1

		MARS1	CYP27B1
Description		methionyl-tRNA synthetase 1	cytochrome P450 family 27 subfamily B member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Outer Membrane
	Molecular Function	TRNA Binding Methionine-tRNA Ligase Activity ATP Binding	Calcidiol 1-monooxygenase Activity Iron Ion Binding Heme Binding Secalciferol 1-monooxygenase Activity
	Biological Process	TRNA Aminoacylation For Protein Translation Methionyl-tRNA Aminoacylation Cellular Response To Starvation RRNA Transcription Cellular Response To Insulin Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I	Vitamin Metabolic Process Calcium Ion Transport Negative Regulation Of Cell Population Proliferation Negative Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D 24-hydroxylase Activity Bone Mineralization Negative Regulation Of Cell Growth Regulation Of Bone Mineralization Response To Lipopolysaccharide Response To Vitamin D Response To Interferon-gamma Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Vitamin D Catabolic Process Response To Estrogen Positive Regulation Of Keratinocyte Differentiation Decidualization Calcium Ion Homeostasis G1 To G0 Transition Positive Regulation Of Vitamin D Receptor Signaling Pathway
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation	Vitamin D (calciferol) metabolism Vitamins Defective CYP27B1 causes VDDR1A
Drugs			Alfacalcidol
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 19525955 21833088)
Interacting Genes		80 interacting genes: CASK CYP27B1 DUX4 ESR1 HNRNPUL1 MAFK MAPK14 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PPM1F RPS27 SUMO2 TNNT1	8 interacting genes: ATF2 HOXC10 ITGB7 MARS1 MYL6 SMC3 TMEM50B TUT4
Entrez ID		4141	1594
HPRD ID		08864	02031
Ensembl ID		ENSG00000166986	ENSG00000111012
Uniprot IDs		P56192	O15528
PDB IDs		2DJV 4BL7 4BVX 4BVY 5GL7 5GOY 5Y6L
Enriched GO Terms of Interacting Partners?
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