LUM and TRA2B

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		LUM	TRA2B
Description		lumican	transformer 2 beta homolog
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrillar Collagen Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleus Nuclear Inner Membrane Nucleoplasm Spliceosomal Complex Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance	RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding Pre-mRNA Binding Identical Protein Binding
	Biological Process	Visual Perception Response To Organic Cyclic Compound Collagen Fibril Organization Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Response To Growth Factor	Response To Reactive Oxygen Species RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Cerebral Cortex Regionalization Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Response To Glucose Stimulus Embryonic Brain Development
Pathways		Keratan sulfate biosynthesis Keratan sulfate degradation Integrin cell surface interactions ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	mRNA Splicing - Major Pathway RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs		Copper
Diseases
GWAS		Blood protein levels ( 30072576) Intraocular pressure ( 29617998) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure (alcohol consumption interaction) ( 24376456)	Height ( 31562340) Menarche (age at onset) ( 27182965 21102462 25231870) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		5 interacting genes: ACAN COL1A2 GNAQ MMP14 TRA2B	110 interacting genes: - CDK6 CLK1 CLK3 EPM2AIP1 HINFP HIPK3 HNRNPA1 IVNS1ABP LUM MAGOHB MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYPOP NGFR NXF1 PCDHB14 PIK3CA RBMX RBMXL2 RBMY1A1 RBMY1F RBMY1J RNPS1 SREK1 SRPK1 SRPK2 SRSF10 SRSF2 SRSF3 SRSF4 SRSF8 SRSF9 TNPO3 U2AF1 USP13 YTHDC1 YWHAG YWHAZ ZRANB2
Entrez ID		4060	6434
HPRD ID		02793	04097
Ensembl ID		ENSG00000139329	ENSG00000136527
Uniprot IDs		A0A384N669 P51884	P62995
PDB IDs			2CQC 2KXN 2RRA 2RRB
Enriched GO Terms of Interacting Partners?
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