LRP2 and TBR1

		LRP2	TBR1
Description		LDL receptor related protein 2	T-box brain transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Brush Border Membrane Endosome Lumen Receptor Complex Extracellular Exosome	Nucleus
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding SH3 Domain Binding Insulin-like Growth Factor I Binding Cargo Receptor Activity Hormone Binding Chaperone Binding Protein Transporter Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding
	Biological Process	Retinoid Metabolic Process Kidney Development Neural Tube Closure Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Ventricular Compact Myocardium Morphogenesis Ventricular Septum Development Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Sensory Perception Of Sound Cell Population Proliferation Male Gonad Development Protein Transport Metal Ion Transport Negative Regulation Of BMP Signaling Pathway Forebrain Development Aorta Development Vitamin D Metabolic Process Negative Regulation Of Apoptotic Process Response To Leptin Transcytosis Positive Regulation Of Neurogenesis Positive Regulation Of Protein Kinase B Signaling Vagina Development Coronary Artery Morphogenesis Pulmonary Artery Morphogenesis Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Growth Factor Stimulus Amyloid-beta Clearance Neuron Projection Arborization Transport Across Blood-brain Barrier Folate Import Across Plasma Membrane Positive Regulation Of Lysosomal Protein Catabolic Process	Conditioned Taste Aversion Cell Fate Specification Regulation Of Transcription By RNA Polymerase II Brain Development Specification Of Animal Organ Identity Regulation Of Neuron Projection Development Amygdala Development Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Development Hindbrain Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Axon Guidance
Pathways		Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport
Drugs		Urokinase Insulin pork Gentamicin
Diseases
GWAS		Anorexia nervosa ( 21079607) Blood pressure (smoking interaction) ( 25189868) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 29779033 29124443 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Gout ( 33832965) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hyperuricemia ( 29124443) Macular thickness ( 30535121) Optic disc size ( 31809533) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Relapse in multiple sclerosis ( 28739605) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29124443 29403010) Urate levels ( 31578528 20139978)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Educational attainment ( 25201988) Intelligence (MTAG) ( 29326435) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990)
Interacting Genes		57 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU COL3A1 CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 EIPR1 GALNT3 GC GIPC1 GPRASP1 HK3 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TANK TBR1 TG THBS1 TLN1 TTR	5 interacting genes: CASK FOXP2 HOXA1 LRP2 MYCBP2
Entrez ID		4036	10716
HPRD ID		02509	07055
Ensembl ID		ENSG00000081479	ENSG00000136535
Uniprot IDs		P98164 Q7Z5C0 Q7Z5C1	Q16650
PDB IDs		2M0P
Enriched GO Terms of Interacting Partners?
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