HiPPIP

LPA and MMP12

  • Number of citations of the paper that reports this interaction (PubMedID 10187779)
  • 4
  • Data Source:
  • HPRD (in vitro)

LPA

MMP12
Description lipoprotein(a) matrix metallopeptidase 12
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Abdominal aortic aneurysm ( 32981348)
  • Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081)
  • Aortic valve stenosis ( 29511194)
  • Aortic-valve calcification ( 23388002)
  • Apolipoprotein A1 levels ( 32203549 33730874)
  • Apolipoprotein B levels ( 32203549)
  • Blood protein levels ( 28240269)
  • Body mass index ( 26426971)
  • Body mass index (age>50) ( 26426971)
  • Body mass index x sex x age interaction (4df test) ( 26426971)
  • Body shape index ( 34021172)
  • C-reactive protein levels ( 33339817)
  • Calcific aortic valve stenosis ( 32141789)
  • Cholesterol, total ( 24097068 28270201 25961943 20686565)
  • Coronary artery disease ( 32469254 29212778 24262325 30104761 26343387 28714974 33020668)
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
  • Coronary artery disease in diabetes ( 30003307)
  • Coronary artery disease or ischemic stroke ( 24262325)
  • Coronary artery disease or large artery stroke ( 24262325)
  • Coronary heart disease ( 19198611 21378990)
  • End stage renal disease x APOL1 genotype interaction ( 29885931)
  • HDL cholesterol ( 25961943 20686565)
  • HDL cholesterol levels ( 32203549)
  • HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Heart failure ( 31919418)
  • High density lipoprotein cholesterol levels ( 33339817)
  • Hip circumference adjusted for BMI ( 34021172)
  • Ischemic stroke (large artery atherosclerosis) ( 29531354)
  • LDL cholesterol ( 24097068 30275531 25961943 20686565)
  • LDL cholesterol levels ( 32203549)
  • LDL cholesterol levels in current drinkers ( 30698716)
  • LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Lipid or lipoprotein levels ( 23696881)
  • Lipoprotein (a) levels ( 26377243 30108283 33115273 28512139)
  • Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284)
  • Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334)
  • Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643)
  • Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms ( 28512139)
  • Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302)
  • Low density lipoprotein cholesterol levels ( 32154731 33339817)
  • Low density lipoprotein cholesterol levels (on statin treatment) ( 31969989)
  • Lp (a) levels ( 21900290 19124843)
  • Medication use (agents acting on the renin-angiotensin system) ( 31015401)
  • Medication use (antithrombotic agents) ( 31015401)
  • Medication use (beta blocking agents) ( 31015401)
  • Medication use (HMG CoA reductase inhibitors) ( 31015401)
  • Medication use (salicylic acid and derivatives) ( 31015401)
  • Medication use (vasodilators used in cardiac diseases) ( 31015401)
  • Metabolic syndrome ( 31589552)
  • Metabolite levels (lipoprotein measures) ( 27005778)
  • Minimum ankle–brachial index ( 31285632)
  • Monocyte early outgrowth colony forming units ( 21493818)
  • Myocardial infarction ( 33532862 26343387)
  • Parental lifespan ( 30642433 29030599)
  • Parental longevity (both parents in top 10%) ( 29227965)
  • Parental longevity (combined parental age at death) ( 29227965)
  • Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
  • Parental longevity (father's age at death) ( 31484785 29227965)
  • Parental longevity (father's attained age) ( 29227965)
  • Parental longevity (mother's age at death or mother's attained age) ( 31484785)
  • Parental longevity (mother's age at death) ( 29227965)
  • Parental longevity (mother's attained age) ( 29227965)
  • Peripheral artery disease ( 31285632)
  • Plasma plasminogen levels ( 25208887)
  • Plateletcrit ( 32888494)
  • Protein quantitative trait loci ( 18464913)
  • Response to statin therapy ( 22368281)
  • Response to statins (LDL cholesterol change) ( 25350695 22331829 31969989)
  • Response to statins (LDL cholesterol percent change) ( 31969989)
  • Total cholesterol levels ( 28334899 33339817 30275531)
  • Triglyceride levels ( 32203549 32154731)
  • Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Triglycerides ( 30275531 25961943)
  • Urinary albumin excretion ( 32277301)
  • Waist-hip index ( 34021172)
  • Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes 9 interacting genes: APOH CANX CELA1 ELANE FBLN5 FGB FN1 LRP2 MMP12 5 interacting genes: APP F12 LPA PLAUR TFPI
Entrez ID 4018 4321
HPRD ID 01063 03027
Ensembl ID ENSG00000198670 ENSG00000262406
Uniprot IDs P39900
PDB IDs 1JIZ 1JK3 1OS2 1OS9 1RMZ 1ROS 1UTT 1UTZ 1Y93 1YCM 1Z3J 2HU6 2JXY 2K2G 2K9C 2KRJ 2MLR 2MLS 2N8R 2OXU 2OXW 2OXZ 2POJ 2W0D 2WO8 2WO9 2WOA 2Z2D 3BA0 3EHX 3EHY 3F15 3F16 3F17 3F18 3F19 3F1A 3LIK 3LIL 3LIR 3LJG 3LK8 3LKA 3N2U 3N2V 3NX7 3RTS 3RTT 3TS4 3TSK 3UVC 4EFS 4GQL 4GR0 4GR3 4GR8 4GUY 4H30 4H49 4H76 4H84 4I03 4IJO 5CXA 5CZM 5D2B 5D3C 5I0L 5I2Z 5I3M 5I43 5I4O 5L79 5L7F 5LAB 5N5J 5N5K 6EKN 6ELA 6ENM 6EOX 6RD0 6RLY
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
Tagcloud (Intersection) ?