LIMK2 and CDC42BPA

Number of citations of the paper that reports this interaction (PubMedID 11340065)
28

Data Source:
HPRD (in vitro)

		LIMK2	CDC42BPA
Description		LIM domain kinase 2	CDC42 binding protein kinase alpha
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cis-Golgi Network Centrosome Perinuclear Region Of Cytoplasm Mitotic Spindle	Cytoplasm Cytosol Cytoskeleton Cell-cell Junction Lamellipodium Cell Leading Edge Actomyosin Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Spermatogenesis Phosphorylation Actin Cytoskeleton Organization Astral Microtubule Organization Establishment Of Vesicle Localization Head Development Cornea Development In Camera-type Eye Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly	Protein Phosphorylation Cell Migration Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Intracellular Signal Transduction
Pathways		EPHB-mediated forward signaling Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs	CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Fish- and plant-related diet ( 32066663) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Oily fish consumption ( 32066663) Paclitaxel-induced neuropathy ( 23776197) Pork consumption ( 32066663) Red cell distribution width ( 32888494) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes nephropathy ( 21150874)	Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 31152163) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Diastolic blood pressure ( 28135244) Low density lipoprotein cholesterol levels ( 33339817) Macular thickness ( 30535121) Mercury levels ( 26025379) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Optic cup area ( 25631615 31798171) Optic disc area ( 25631615 31798171 28073927) Optic disc size ( 31809533) SAPHO syndrome ( 33816493) Smoking initiation ( 33082346) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		13 interacting genes: CDC42BPA CFL1 FBXO7 FCGR2A GSN H1-1 HIPK3 LIMK1 MBP NF1 PARD3 ROCK1 RPS6KA1	10 interacting genes: CDC42 CDC42BPB LIMK1 LIMK2 MYL2 MYL9 PPM1A PPP1R12C SNAPIN TAF1
Entrez ID		3985	8476
HPRD ID		03585	04562
Ensembl ID		ENSG00000182541	ENSG00000143776
Uniprot IDs		A0A024R1H6 A0A024R1M2 P53671	Q5VT25
PDB IDs		1X6A 4TPT 5NXD
Enriched GO Terms of Interacting Partners?
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