ARHGAP1 and HMGCR

Number of citations of the paper that reports this interaction (PubMedID 14697242)
23

Data Source:
HPRD (two hybrid)

		ARHGAP1	HMGCR
Description		Rho GTPase activating protein 1	3-hydroxy-3-methylglutaryl-CoA reductase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Sorting Endosome	Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Small GTPase Binding Cadherin Binding	Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Binding Identical Protein Binding Protein Phosphatase 2A Binding NADPH Binding Coenzyme A Binding
	Biological Process	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Endosomal Transport Transferrin Transport Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Endocytic Recycling	Cholesterol Biosynthetic Process Ubiquinone Metabolic Process Aging Response To Nutrient Isoprenoid Biosynthetic Process Visual Learning Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Coenzyme A Metabolic Process Sterol Biosynthetic Process Positive Regulation Of Stress-activated MAPK Cascade Bile Acid Signaling Pathway Negative Regulation Of Protein Catabolic Process Cholesterol Homeostasis Negative Regulation Of MAP Kinase Activity Myoblast Differentiation Response To Ethanol Positive Regulation Of Vasoconstriction Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Protein Secretion Negative Regulation Of Wound Healing Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Triglyceride Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Negative Regulation Of Amyloid-beta Clearance
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND2 GTPase cycle	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs			NADH Pravastatin Lovastatin Cerivastatin Simvastatin Atorvastatin Fluvastatin Rosuvastatin Coenzyme A (S)-Hmg-Coa Nicotinamide adenine dinucleotide phosphate Meglutol 1,4-Dithiothreitol TAK-475 Mevastatin Pitavastatin Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Bone mineral density (hip) ( 19801982) Experiencing mood swings ( 29500382) Fasting glucose ( 34059833) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Femoral neck bone mineral density ( 22504420) Neurociticism ( 29500382) Reaction time ( 29844566) Schizophrenia ( 29483656) Suffering from nerves ( 29500382)	Apolipoprotein B levels ( 32203549) Body mass index ( 20935630) Cholesterol ( 31902109) Cholesterol, total ( 24097068 28270201 19060911 25961943 20686565 26582766) Coronary artery disease ( 33020668) LDL cholesterol ( 24097068 18802019 18193044 20864672 19060906 19060911 25961943 20686565 26582766) LDL cholesterol levels ( 32203549 28334899 31087446) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 32154731 29403010 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 21909109 23823483) Metabolite levels (lipoprotein measures) ( 27005778) Quantitative traits ( 19197348) Total cholesterol levels ( 28334899 31087446 33339817 30275531) Type 2 diabetes ( 32499647)
Interacting Genes		27 interacting genes: ADGRB2 AGTRAP BDNF BNIP2 BNIPL CDC42 CHEK2 EPB41L1 HMGCR HSP90AB1 ITPR1 KIF1B LINC01554 MTNR1B OGT PIK3R1 PTPN11 RAC1 RASA1 RHOA RHOC SH3GL1 SMARCD3 SRC TAX1BP1 TUBA4A WAS	4 interacting genes: ARHGAP1 INSIG1 PRKACA STARD13
Entrez ID		392	3156
HPRD ID		04108	00836
Ensembl ID		ENSG00000175220	ENSG00000113161
Uniprot IDs		Q07960	A0A024RAP2 P04035
PDB IDs		1AM4 1GRN 1OW3 1RGP 1TX4 2NGR 5M6X 5M70 6R3V	1DQ8 1DQ9 1DQA 1HW8 1HW9 1HWI 1HWJ 1HWK 1HWL 2Q1L 2Q6B 2Q6C 2R4F 3BGL 3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB
Enriched GO Terms of Interacting Partners?
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