LIN28B and MIRLET7F1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
92

Data Source:
BioGRID (unspecified method)

		LIN28B	MIRLET7F1
Description		lin-28 homolog B	microRNA let-7f-1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol	Extracellular Space Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Sequence-specific Double-stranded DNA Binding	MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	MiRNA Catabolic Process Pre-miRNA Processing RNA 3'-end Processing RNA Destabilization Positive Regulation Of MiRNA Catabolic Process Negative Regulation Of Pre-miRNA Processing Negative Regulation Of Primary MiRNA Processing	Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of TOR Signaling Negative Regulation Of Interleukin-17 Production Gene Silencing By MiRNA Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta
Pathways
Drugs
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Age at voice drop ( 27182965) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Digit length ratio ( 29659830 20303062) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Height ( 28552196 20881960 25282103 25429064 23563607 18391950 18391951) Hip circumference adjusted for BMI ( 34021172 25673412) Insomnia ( 32332799) Intraocular pressure ( 29617998 30054594) Major depressive disorder ( 27479909) Menarche (age at onset) ( 19448620 19448622 19448623 27182965 21102462 23667675 29773799 25231870) Menarche and menopause (age at onset) ( 19448621) Metabolite levels ( 23823483) Neuroblastoma ( 22941191) Pubertal anthropometrics ( 23449627) Puberty onset ( 24770850) Puberty onset (breast development) ( 24770850) Schizophrenia ( 28991256 30285260) Sporadic neuroblastoma ( 28545128) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500) White blood cell count ( 32888494)
Interacting Genes		45 interacting genes: KAT2B MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR143 MIR145 MIR15A MIR19B1 MIR200A MIR205 MIR206 MIR221 MIR25 MIR29A MIR29B1 MIR29B2 MIR31 MIR34A MIR34B MIR429 MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I TRIM71	93 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B ATXN2L C1QBP CELF1 DARS1 DDX1 DDX21 DDX3X DDX3Y DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FAM98B FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PUM1 PUM2 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RBM47 RTCA RTCB SART3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		389421	406888
HPRD ID		13366
Ensembl ID		ENSG00000187772	ENSG00000199072
Uniprot IDs		A0A1B0GVD3 Q6ZN17
PDB IDs		4A4I
Enriched GO Terms of Interacting Partners?
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