INKA1 and PAK5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		INKA1	PAK5
Description		inka box actin regulator 1	p21 (RAC1) activated kinase 5
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Synapse
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Catalytic Activity	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS			Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		10 interacting genes: APP C1orf109 DDX6 GPANK1 KIF9 PAK4 PAK5 TRIM55 TRIM63 ZNF417	34 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 TSGA10 TUBGCP4 UXT
Entrez ID		389119	57144
HPRD ID		14210	06423
Ensembl ID		ENSG00000185614	ENSG00000101349
Uniprot IDs		Q96EL1	B0AZM9 Q9P286
PDB IDs		4XBR 4XBU	2F57
Enriched GO Terms of Interacting Partners?
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