KRT31 and PDGFRB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KRT31	PDGFRB
Description		keratin 31	platelet derived growth factor receptor beta
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Intermediate Filament Extracellular Exosome	Nucleus Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Membrane Apical Plasma Membrane Intrinsic Component Of Plasma Membrane Cytoplasmic Vesicle Lysosomal Lumen Intracellular Membrane-bounded Organelle Receptor Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Growth Factor Binding Enzyme Binding Protein Kinase Binding Vascular Endothelial Growth Factor Binding Phosphatidylinositol 3-kinase Binding Platelet-derived Growth Factor Binding
	Biological Process	Cytoskeleton Organization Epidermis Development	Angiogenesis Glycosaminoglycan Biosynthetic Process Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Aging Positive Regulation Of Cell Population Proliferation Male Gonad Development Response To Toxic Substance Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Response To Estradiol Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Retinoic Acid Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Kinase Activity Response To Fluid Shear Stress Positive Regulation Of Rho Protein Signal Transduction Cell Migration Involved In Vasculogenesis Metanephric Mesenchymal Cell Migration Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Aorta Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Wound Healing Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Estrogen Positive Regulation Of Mitotic Nuclear Division Phosphatidylinositol Metabolic Process Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Inner Ear Development Positive Regulation Of Chemotaxis Cardiac Myofibril Assembly Response To Hyperoxia Cell Chemotaxis Lung Growth Cell Migration Involved In Coronary Angiogenesis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Smooth Muscle Cell Chemotaxis Metanephric Mesenchyme Development Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Capillary Formation Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Positive Regulation Of Calcium Ion Import Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of DNA Biosynthetic Process
Pathways		Keratinization Formation of the cornified envelope	PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Becaplermin Sorafenib Imatinib Dasatinib Sunitinib XL999 XL820 Pazopanib Midostaurin Regorafenib Nintedanib Polaprezinc Trapidil Foreskin fibroblast (neonatal) Fostamatinib Erdafitinib Pexidartinib Ripretinib Pralsetinib
Diseases
GWAS		Brown vs. black hair color ( 30531825)	Blood protein levels ( 30072576 29875488 28240269) Cytokine network levels (multivariate analysis) ( 31679650) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory biomarkers (multivariate analysis) ( 33110245) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252)
Interacting Genes		356 interacting genes: A1CF ABI2 ABI3 ABL1 ACTR10 AGR2 AGXT AIMP2 AKR7A3 ALDH3B1 AMOT AMOTL2 ANKRD36BP1 ANKS1A AQP1 AQP5 ARHGAP35 ARID3A ARMC7 ARSJ ASMTL ASPSCR1 ATG9A ATN1 ATXN7L1 ATXN7L2 AVPI1 B4GALT7 BAD BCAS2 BEX1 BEX2 BFSP2 BHLHA9 BRME1 BTC BYSL C19orf73 C1orf109 C1orf216 C2CD6 C3 C5orf49 C5orf60 CA6 CARD9 CATIP CATSPER1 CBX8 CCDC112 CCDC116 CCDC120 CCDC146 CCDC17 CCDC187 CCDC196 CCDC198 CCDC93 CCER1 CCHCR1 CCNC CD33 CDC20B CDK18 CDKN1A CDKN2C CDR2L CEP57 CEP57L1 CEP70 CFAP206 CFAP53 CHCHD2 CHRNG CLCNKA CLDN19 CLDN2 CLEC18A CNNM3 CNTF COA5 COMT COX5A COX5B CRACR2A CREB5 CRH CTSG CXCL16 CYSRT1 DEF6 DGCR6L DHX37 DMRT3 DOCK2 DTNB EIF4E2 EIF4G1 ENKD1 EPDR1 EXOC8 EXOSC5 FADS2 FAM110A FAM124B FAM50B FAM71C FAM74A4 FAM90A1 FARS2 FBF1 FBXW5 FGF16 FKBP1B FOXB1 FRS3 GAD1 GADD45GIP1 GEM GFAP GFOD1 GLRX3 GNAI2 GNE GNG10 GNG5 GOLGA6L2 GPS2 GSTP1 HAPLN2 HAUS1 HBA1 HBA2 HBZ HCK HDAC4 HGS HNRNPLL HOXA1 HOXB5 HS6ST1 HSD3B7 HSF4 HSPA12B HSPD1 HYAL2 ICAM4 IL16 INPP5D INPP5K INSR ITGB2 ITGB4 ITGB5 JOSD1 KCTD9 KDM1A KIAA1217 KIFC3 KLC1 KLC4 KLHL38 KLK8 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 KRTAP4-12 KRTAP5-6 KRTAP9-2 KRTAP9-3 LATS1 LCE1B LCE3C LCE3D LCE3E LCE4A LENG1 LIF LIN37 LINC00526 LMF2 LMNTD2 LMO3 LMO4 LONRF1 LRRC41 MAB21L2 MAP3K7CL MAPKBP1 MARK4 MID2 MOS MRPL40 MSRB3 MTA1 MXD3 MXI1 MYOM1 NAV1 NAXD NEK6 NODAL NPBWR2 NTAQ1 NUDT16L1 NUFIP2 OTUB2 OTX1 P2RX7 P3H3 PBX3 PDE4DIP PDGFRB PGAP6 PGLS PHC2 PHLDA1 PIN1 PKN1 PKN3 PKP2 PLEKHN1 POLDIP3 POU4F2 POU4F3 PPP1R18 PPP1R32 PRF1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRPH PRR19 PRR35 PSMA1 PSMB1 PSMC5 PSMG2 PSPC1 PTGER3 PTPMT1 R3HDM2 RAB33A RADIL RAMAC RCOR3 RHPN1 RIBC1 RPS19BP1 RPUSD3 RSPH14 RTP5 SAMD11 SCNM1 SEC14L4 SEMA4C SHC3 SHFL SHISA6 SIRPA SLC15A3 SLC23A1 SLC25A42 SLC25A6 SMARCD1 SMARCE1 SMCP SMG9 SNAI1 SNRNP25 SPATA24 SPG21 SPON2 SPRING1 SPRY1 SRSF2 SSX2IP STK16 TACO1 TAPBPL TCEANC TEAD4 TEPSIN TEX28 TEX33 TFAP2D THAP7 TLE5 TMEM106C TMEM174 TMEM231 TMSB4X TRAF4 TRIML2 TROAP TSEN54 TSG101 TSHZ3 TSNAX TTC23 TTC9C TXLNA TYK2 UACA UBASH3A USHBP1 USP2 UTP23 UXT VASN VPS9D1 WDR25 WFDC6 ZDHHC1 ZFHX3 ZFYVE21 ZGPAT ZIC1 ZNF124 ZNF148 ZNF20 ZNF250 ZNF414 ZNF417 ZNF446 ZNF564 ZNF569 ZNF572 ZNF587 ZNF688 ZNF69 ZNF835 ZNRF2P1	84 interacting genes: ABL1 ABL2 ARAF BAG1 CAV1 CAV3 CBL CDK14 CDX1 CEP76 CHRM3 COPA COPB1 CRK EGFR EIF2AK2 ERBB2 FAXDC2 FGFR1 FYN GAB1 GRB10 GRB14 GRB2 GRB7 ITGB3 ITK JAK1 JAK2 KLHL12 KPRP KRT31 KRT34 KRTAP10-9 KRTAP12-3 KRTAP4-12 MITF NCK1 NCK2 NEDD4 PDAP1 PDGFB PDGFD PDGFRA PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PLAUR PLCG1 PPM1L PRDX2 PTEN PTK2 PTPN1 PTPN11 PTPN2 PTPN6 PTPRJ RAF1 RASA1 RPS6KB2 S1PR1 SHC1 SLC9A3R1 SLC9A3R2 SNX1 SNX2 SNX4 SOCS1 SRC STAT1 STAT3 STAT5A STAT5B SYNGAP1 TNK2 TPTE TRIP6 TUFM TYK2 VAV1 YES1
Entrez ID		3881	5159
HPRD ID		03047	01423
Ensembl ID		ENSG00000094796	ENSG00000113721
Uniprot IDs		Q15323	P09619 Q59F04
PDB IDs			1GQ5 1H9O 1LWP 1SHA 2IUI 2L6W 2PLD 2PLE 3MJG
Enriched GO Terms of Interacting Partners?
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