KRT1 and KRT6A

		KRT1	KRT6A
Description		keratin 1	keratin 6A
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Membrane Keratin Filament Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Nucleus Cytosol Membrane Keratin Filament Extracellular Exosome
	Molecular Function	Protein Binding Carbohydrate Binding Structural Constituent Of Skin Epidermis Signaling Receptor Activity Protein Heterodimerization Activity	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Peptide Cross-linking Fibrinolysis Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier	Negative Regulation Of Cytolysis By Symbiont Of Host Cells Morphogenesis Of An Epithelium Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Cell Differentiation Wound Healing Defense Response To Gram-positive Bacterium Cytolysis By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Entry Of Bacterium Into Host Cell
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs		Zinc Copper Zinc acetate	Zinc Zinc acetate
Diseases
GWAS			Cutaneous squamous cell carcinoma ( 32041948)
Interacting Genes		54 interacting genes: - AMOTL2 CALB2 CSTA DSP EVPL F12 FANCA FANCC FFAR2 GOLGA2 GOLGA6L9 HAUS1 HMG20A HOOK2 IVL KNG1 KRT13 KRT14 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT5 KRT6A LINC00839 LORICRIN MBL2 NINL NUP62 OGT PDE4DIP PI3 PRKCE RINT1 SGTB TFIP11 TLCD4 TRIM54 U2AF1 UBE3A YWHAQ	50 interacting genes: BEX2 CCDC85B CCR1 DSP GEM GNL1 GOLGA2 HGS KDM1A KIFC3 KRT1 KRT13 KRT15 KRT16 KRT17 KRT18 KRT19 KRT25 KRT26 KRT27 KRT28 KRT3 KRT31 KRT34 KRT35 KRT36 KRT38 KRT4 KRT40 KRT5 KRT6B KRT7 LMNA MTUS2 NCALD NUP62 PRPH RND1 SGTA SMARCB1 TARBP2 TCHP TFIP11 TMBIM6 TRIM23 TRIM54 TSGA10 TXLNB UBQLN2 WASHC3
Entrez ID		3848	3853
HPRD ID		00763	01011
Ensembl ID		ENSG00000167768	ENSG00000205420
Uniprot IDs		P04264	A0A0S2Z428 P02538
PDB IDs		4ZRY 6E2J 6UUI	5KI0
Enriched GO Terms of Interacting Partners?
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