ARF6 and ARHGAP10

Number of citations of the paper that reports this interaction (PubMedID 16527809)
28

Data Source:
BioGRID (pull down, pull down)

		ARF6	ARHGAP10
Description		ADP ribosylation factor 6	Rho GTPase activating protein 10
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Membrane Endocytic Vesicle Filopodium Membrane Early Endosome Membrane Cleavage Furrow Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Glutamatergic Synapse	Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Thioesterase Binding Protein N-terminus Binding	GTPase Activator Activity Protein Binding
	Biological Process	Liver Development Intracellular Protein Transport Cell Cycle Cell Adhesion Nervous System Development Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Myeloid Cell Apoptotic Process Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development	Cytoskeleton Organization Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	Regulation of PAK-2p34 activity by PS-GAP/RHG10 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid
Diseases
GWAS		Erythema nodosum in inflammatory bowel disease ( 24487271) Ferritin levels ( 33491795)	Atrial fibrillation ( 30061737 29892015) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Liver enzyme levels (alkaline phosphatase) ( 33972514) QT interval ( 20031603) Resting heart rate ( 27798624) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		43 interacting genes: AGAP1 ALDH5A1 AP1B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CYTH1 CYTH2 EXOC5 EZR HTR2A IKBKG ITSN1 LSM7 MEOX2 MGAM MT2A PALS1 PIP5K1A PIP5K1C PLD1 PRPF39 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 RPLP1 SMAP1 SMARCC2 SPAG9 TOGARAM1 ZNF709	10 interacting genes: ANKS1A ARF6 CDC42 HRAS PAK2 PKN1 PKN3 RHOA SH3BP2 YWHAQ
Entrez ID		382	79658
HPRD ID		02714	07949
Ensembl ID		ENSG00000165527	ENSG00000071205
Uniprot IDs		P62330	A0A2X0SFB3 A1A4S6
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU	2MIO
Enriched GO Terms of Interacting Partners?
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