KLK2 and IGFBP2

Number of citations of the paper that reports this interaction (PubMedID 11358513)
18

Data Source:
HPRD (in vitro)

		KLK2	IGFBP2
Description		kallikrein related peptidase 2	insulin like growth factor binding protein 2
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GO Annotations	Cellular Component	Extracellular Region Secretory Granule Extracellular Exosome	Extracellular Region Extracellular Space Apical Plasma Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Zymogen Activation	Signal Transduction Female Pregnancy Aging Response To Nutrient Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Lithium Ion Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Regulation Of Growth Positive Regulation Of Activated T Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Response To Glucocorticoid Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322 34012061) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)	Glomerular filtration rate (creatinine) ( 28452372) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) Mitral valve prolapse ( 26301497) Thyroid stimulating hormone levels ( 25743335) Type 2 diabetes ( 26818947)
Interacting Genes		16 interacting genes: A2M APP AR IGFBP2 JADE2 MET POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2	9 interacting genes: BMPR2 CASP10 GSDMB IGF1 IGF2 INO80B KLK2 RPS6KA1 TF
Entrez ID		3817	3485
HPRD ID		01006	00898
Ensembl ID		ENSG00000167751	ENSG00000115457
Uniprot IDs		A0A024R4J4 A0A024R4N3 B4DU77 P20151	C9JMY1 P18065
PDB IDs		4NFE 4NFF	2H7T
Enriched GO Terms of Interacting Partners?
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