KCNN4 and CNIH3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KCNN4	CNIH3
Description		potassium calcium-activated channel subfamily N member 4	cornichon family AMPA receptor auxiliary protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Vesicle Neuron Projection Neuronal Cell Body	Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Dendrite AMPA Glutamate Receptor Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Dendritic Shaft Synapse Postsynaptic Membrane
	Molecular Function	Potassium Channel Activity Protein Binding Calmodulin Binding Calcium-activated Potassium Channel Activity Small Conductance Calcium-activated Potassium Channel Activity Protein Phosphatase Binding Intermediate Conductance Calcium-activated Potassium Channel Activity	Protein Binding Channel Regulator Activity
	Biological Process	Immune System Process Ion Transport Potassium Ion Transport Calcium Ion Transport Cell Volume Homeostasis Defense Response Stabilization Of Membrane Potential Phospholipid Translocation Saliva Secretion Positive Regulation Of Protein Secretion Positive Regulation Of T Cell Receptor Signaling Pathway Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport	Vesicle-mediated Transport Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Regulation Of AMPA Receptor Activity
Pathways		Ca2+ activated K+ channels	COPII-mediated vesicle transport Cargo concentration in the ER
Drugs		Clotrimazole Quinine Procaine Miconazole Halothane Trimebutine
Diseases
GWAS		Breast cancer ( 23535729) Granulocyte percentage of myeloid white cells ( 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)	Cancer ( 29299148) Gut microbiota relative abundance (Streptococcus) ( 33208821) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 32888494) Neonatal white matter microstructure ( 33009551) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Opioid dependence ( 26239289) White blood cell count ( 32888494)
Interacting Genes		9 interacting genes: BIK CALM1 CNIH3 FXYD3 GPR152 PMP22 PRKAG1 SLC30A2 STX1B	29 interacting genes: AQP6 BIK CD79A CEACAM3 CLDN20 DNAH14 ERGIC3 FAM210B FNDC9 GPX8 KCNN4 LEUTX LMNA LRRC25 NEMP1 ODF4 PLD3 SLC16A2 SMIM3 SORT1 STOM SUSD3 TMEM14B TMEM237 TMEM31 TMEM52B TMEM80 TMPRSS2 VSIR
Entrez ID		3783	149111
HPRD ID		04130	08799
Ensembl ID		ENSG00000104783	ENSG00000143786
Uniprot IDs		O15554	Q8TBE1
PDB IDs		6CNM 6CNN 6CNO 6D42
Enriched GO Terms of Interacting Partners?
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