KCNK1 and TCIRG1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		KCNK1	TCIRG1
Description		potassium two pore domain channel subfamily K member 1	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Apical Plasma Membrane Dendrite Brush Border Membrane Potassium Channel Complex Perikaryon Intracellular Membrane-bounded Organelle Recycling Endosome Synaptic Membrane Inward Rectifier Potassium Channel Complex	Vacuolar Proton-transporting V-type ATPase, V0 Domain Nucleus Lysosomal Membrane Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding Potassium Ion Leak Channel Activity Identical Protein Binding	Transporter Activity Protein Binding Proton Transmembrane Transporter Activity ATPase Binding
	Biological Process	Potassium Ion Transport Stabilization Of Membrane Potential Response To Nicotine Sodium Ion Transmembrane Transport Regulation Of Resting Membrane Potential Potassium Ion Transmembrane Transport	Autophagosome Assembly Ossification Osteoclast Proliferation Cellular Calcium Ion Homeostasis Apoptotic Process Inflammatory Response Cellular Defense Response Vacuolar Acidification Protein Catabolic Process In The Vacuole Positive Regulation Of Cell Population Proliferation Regulation Of Proton Transport Response To Silver Ion Gene Expression Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Macroautophagy Optic Nerve Development Establishment Of Cell Polarity B Cell Differentiation T Cell Differentiation Osteoclast Differentiation Ruffle Organization Protein Localization To Organelle Memory T Cell Activation T-helper 1 Cell Activation T Cell Homeostasis Tooth Eruption Bone Resorption Regulation Of Osteoblast Differentiation Regulation Of Insulin Secretion Establishment Of Vesicle Localization Retina Development In Camera-type Eye Hematopoietic Stem Cell Homeostasis Enamel Mineralization Cellular Response To Cytokine Stimulus Phagosome Acidification Dentin Mineralization Proton Transmembrane Transport
Pathways		Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Phase 4 - resting membrane potential	ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Ibutilide Quinidine Quinidine barbiturate	Tiludronic acid
Diseases
GWAS		Cognitive function ( 28808816) Diabetic retinopathy ( 21441570) Periodontal microbiota ( 22699663) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Heel bone mineral density ( 30598549) Reticulocyte count ( 32888494)
Interacting Genes		13 interacting genes: AQP6 CDIPT CREB3 CREB3L1 ERGIC3 KRTAP10-3 LMNA SENP1 STOM TCIRG1 TMEM139 TMEM14B UBE2I	8 interacting genes: CYTH2 DNAH3 HSP90AA1 KCNK1 MTDH POGZ TERF1 TLX3
Entrez ID		3775	10312
HPRD ID		03447	05207
Ensembl ID		ENSG00000135750	ENSG00000110719
Uniprot IDs		A0A024R3T2 O00180	A0A024R5E5 Q13488
PDB IDs		3UKM
Enriched GO Terms of Interacting Partners?
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