ASPG and CEACAM6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ASPG	CEACAM6
Description		asparaginase	CEA cell adhesion molecule 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Space Plasma Membrane Cell Surface Apical Plasma Membrane Anchored Component Of Membrane Azurophil Granule Membrane
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Asparaginase Activity Lysophospholipase Activity Protein Binding Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Phosphatidyl Phospholipase B Activity	Protein Binding Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Aspartate Family Amino Acid Metabolic Process Lipid Catabolic Process	Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Negative Regulation Of Anoikis
Pathways		Aspartate and asparagine metabolism	Fibronectin matrix formation Cell surface interactions at the vascular wall Neutrophil degranulation
Drugs		Procaine
Diseases
GWAS		Blood metabolite levels ( 24816252) Body mass index ( 26426971) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free asparagine levels ( 30659259) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748)	Serum carcinoembryonic antigen levels ( 31666285)
Interacting Genes		12 interacting genes: C20orf85 CEACAM6 DMRT3 GSDMD MYOZ3 RTP5 SGK1 SHC3 TEKT3 TMEM115 USP2 VPS25	32 interacting genes: APP ASPG CARTPT CEACAM1 CEACAM5 CEACAM7 CEACAM8 CIB1 CSTF2 EXOC3L1 FOXH1 GCM2 GPANK1 HGS HPCAL4 KANK2 MSS51 MYOZ1 PITX1 POM121 QRICH1 RHOXF2 SHC3 SMARCD1 TLX3 TNXB UBQLN2 VENTX VEZF1 WWOX ZMYND19 ZNF76
Entrez ID		374569	4680
HPRD ID		19180	01233
Ensembl ID		ENSG00000166183	ENSG00000086548
Uniprot IDs		Q86U10	P40199
PDB IDs			4WHC 4WTZ 4Y8A 4YIQ
Enriched GO Terms of Interacting Partners?
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