JAK1 and STAM

Number of citations of the paper that reports this interaction (PubMedID 9133424)
27

Data Source:
HPRD (in vivo)

		JAK1	STAM
Description		Janus kinase 1	signal transducing adaptor molecule
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Focal Adhesion Membrane	Cytosol Early Endosome Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding CCR5 Chemokine Receptor Binding Metal Ion Binding	Protein Binding Phosphatidylinositol Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Protein Phosphorylation Receptor Signaling Pathway Via JAK-STAT Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Intracellular Signal Transduction Interleukin-2-mediated Signaling Pathway Response To Antibiotic Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Interleukin-6-mediated Signaling Pathway Protein Localization To Cell-cell Junction Positive Regulation Of Sprouting Angiogenesis	Signal Transduction Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly
Pathways		Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation ISG15 antiviral mechanism Interleukin-7 signaling Interleukin-7 signaling Other interleukin signaling RAF/MAP kinase cascade Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-2 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-27 signaling Interleukin-27 signaling Interleukin-21 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA signaling Regulation of IFNA signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling	EGFR downregulation Metalloprotease DUBs Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs		Myricetin 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Ruxolitinib Tofacitinib Baricitinib Fostamatinib Fedratinib Filgotinib Upadacitinib Pralsetinib
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Cognitive function in longevity ( 33607172) Core binding factor acute myeloid leukemia ( 27903959) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Liver enzyme levels (alkaline phosphatase) ( 33972514) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Plasma anti-thyroglobulin levels ( 29678681) Platelet count ( 32888494) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		81 interacting genes: ABL1 AGTR1 ANKRD13C BRCA1 BTK CBR1 CCR1 CCR5 CSF2RB CSF3R CXCR4 DAB1 DHX9 EIF2AK2 ELP2 ERBB2 FER FES GAB1 GHR GRB2 H3-4 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK2 JAK3 JAKMIP1 MDK NFYC OSMR P2RY1 P3H1 PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RACK1 RAF1 SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 SYK TEC TNFRSF1A TOP1 TSHR TYK2 USP6 VNN2	21 interacting genes: ARRB1 HGS JAK1 JAK2 JAK3 MAD1L1 MAP3K1 PJA1 PMEPA1 PPP1CA PPP1CC RFFL STAMBP TIMM8A TRIM54 TRIM55 TRIM63 UBC USP15 USP28 USP8
Entrez ID		3716	8027
HPRD ID		00992	03542
Ensembl ID		ENSG00000162434	ENSG00000136738
Uniprot IDs		P23458 Q6P669	B4DZT2 Q92783
PDB IDs		3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01 5E1E 5HX8 5IXD 5IXI 5KHW 5KHX 5L04 5WO4 6AAH 6BBU 6C7Y 6DBN 6ELR 6GGH 6HZU 6N77 6N78 6N79 6N7A 6N7B 6N7C 6N7D 6RSB 6RSC 6RSD 6RSE 6RSH 6SM8 6SMB 6TPE 6TPF 6W8L	2L0A 3F1I 3LDZ
Enriched GO Terms of Interacting Partners?
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