ITGB2 and ICAM1

Number of citations of the paper that reports this interaction (PubMedID 11279101)
53

Data Source:
HPRD (in vivo, in vitro)

		ITGB2	ICAM1
Description		integrin subunit beta 2	intercellular adhesion molecule 1
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Specific Granule Membrane Receptor Complex Plasma Membrane Raft Extracellular Exosome Tertiary Granule Membrane Cytoplasmic Region Ficolin-1-rich Granule Membrane Extracellular Vesicle	Immunological Synapse Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Heat Shock Protein Binding Cargo Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding	Virus Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity
	Biological Process	Microglial Cell Activation Receptor-mediated Endocytosis Phagocytosis, Engulfment Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Cell Migration Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Superoxide Anion Generation Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Receptor Clustering Positive Regulation Of Neutrophil Degranulation Negative Regulation Of Dopamine Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Neuron Death Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Neutrophil Migration Positive Regulation Of Prostaglandin-E Synthase Activity	Ovarian Follicle Development Regulation Of Leukocyte Mediated Cytotoxicity Response To Amphetamine T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Acute Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell Aging Sensory Perception Of Sound Regulation Of Cell Shape Response To Xenobiotic Stimulus Response To Ionizing Radiation Response To Sulfur Dioxide Membrane To Membrane Docking Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels Response To Insulin Cell Adhesion Mediated By Integrin Response To Gonadotropin Response To Amino Acid Positive Regulation Of GTPase Activity Adhesion Of Symbiont To Host Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Ethanol Positive Regulation Of Vasoconstriction Response To Copper Ion Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Calcium Ion Transport Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Alkaloid Cellular Response To Glucose Stimulus Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus T Cell Extravasation Establishment Of Endothelial Intestinal Barrier Establishment Of Sertoli Cell Barrier Regulation Of Ruffle Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Amyloid-beta Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Toll Like Receptor 4 (TLR4) Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling
Drugs			Natalizumab Hyaluronic acid Nafamostat
Diseases
GWAS		Heel bone mineral density ( 28869591) Lymphocyte counts ( 32888494) Neonatal white matter microstructure ( 33009551)	Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 21102463) Height ( 31562340) Inflammatory bowel disease ( 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low white blood cell count (conditioned on rs2814778) ( 29596498) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Pulse pressure ( 27841878) Soluble ICAM-1 ( 21533024 31217265 18604267) White blood cell count ( 32888494)
Interacting Genes		58 interacting genes: ADAMTSL4 APOL2 C3 CD14 CD226 CD82 CHPF COPS3 COPS5 CYSRT1 CYTH1 CYTH2 DAB1 DOK1 EGFR ERG ESM1 FCER2 FHL2 FUT4 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 KRT31 KRTAP10-8 LHFPL5 MS4A7 MTIF3 NBPF19 NOTCH2NLA NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RACK1 RANBP9 RDX SCML1 SHARPIN SYK TLN1 TM4SF18 UPK1B VNN2	28 interacting genes: BCL7B BRAF CALR CYSRT1 EGFR EZR FANCF FGG HDAC1 HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 KEAP1 KIF1A KRTAP10-8 MAP2K7 MC1R MSN MTPN MYO1F SLC3A2 SLCO2B1 SPN TBL3 UBQLN2
Entrez ID		3689	3383
HPRD ID		02506	00996
Ensembl ID		ENSG00000160255	ENSG00000090339
Uniprot IDs		A0A494C0X7 B4E0R1 P05107	A0A384MEK5 P05362
PDB IDs		1JX3 1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72 4NEH 4NEN 5E6R 5E6S 5E6U 5E6V 5E6W 5E6X 5ES4 5XR1 5ZAZ	1D3E 1D3I 1D3L 1IAM 1IC1 1IJ4 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U
Enriched GO Terms of Interacting Partners?
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