AQP9 and APOD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		AQP9	APOD
Description		aquaporin 9	apolipoprotein D
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Cytosolic Ribosome Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Amine Transmembrane Transporter Activity Purine Nucleobase Transmembrane Transporter Activity Pyrimidine Nucleobase Transmembrane Transporter Activity Water Transmembrane Transporter Activity Protein Binding Polyol Transmembrane Transporter Activity Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Urea Channel Activity Carboxylic Acid Transmembrane Transporter Activity	Lipid Transporter Activity Protein Binding Cholesterol Binding
	Biological Process	Water Transport Purine Nucleobase Transport Response To Osmotic Stress Excretion Response To Organic Substance Canalicular Bile Acid Transport Polyol Transport Glycerol Transport Amine Transport Pyrimidine Nucleobase Transport Water Homeostasis Response To Mercury Ion Carboxylic Acid Transport Cellular Response To CAMP Urea Transmembrane Transport Pyrimidine-containing Compound Transmembrane Transport Purine Nucleobase Transmembrane Transport Carboxylic Acid Transmembrane Transport	Response To Reactive Oxygen Species Angiogenesis Glucose Metabolic Process Lipid Metabolic Process Lipid Transport Brain Development Aging Response To Xenobiotic Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Tissue Regeneration Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of T Cell Migration
Pathways		Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins	Transport of fatty acids NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs			Vitamin A Copper
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Glycine levels ( 30837465) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels in HIV infection ( 33109212) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Ischemic stroke ( 26089329) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 23823483 22916037) Serum alkaline phosphatase levels ( 33547301) Small cell lung carcinoma ( 28604730) Stroke ( 26089329) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	HDL cholesterol levels ( 32203549)
Interacting Genes		24 interacting genes: ADAM33 AIG1 APOD CCDC167 CLDN19 CPLX4 CTXN3 CXCL16 EMC6 FATE1 FXYD3 FZD7 GAST HHLA2 IGFBP5 LHFPL5 MIP PAEP SERINC1 SGPL1 SLC38A7 TF TMED9 TMEM109	51 interacting genes: AIG1 APH1A APOA2 AQP9 ATP6V0B ATP6V0E1 BCL2L13 BIK CD53 CD79A CLDN7 CLEC10A CPLX4 CREB3 CREB3L1 ERGIC3 EVI2B FAM209A FFAR2 FKBP7 FPR2 GDAP1 GJA8 GORAB GPR151 GPR42 GPX8 KCNJ6 KIR2DL3 LEPR LMNA MFF MGST3 MTERF2 MTIF3 NCAPH2 PDZK1IP1 POLR2M RHBDL1 SHBG SIGLECL1 SLC10A6 SLC35C2 TEX29 TMEM237 TMEM31 TMEM45B TMEM52B TMEM79 VAPA VSIR
Entrez ID		366	347
HPRD ID		04223	00134
Ensembl ID		ENSG00000103569	ENSG00000189058
Uniprot IDs		H0YK62 O43315	P05090
PDB IDs			2APD 2HZQ 2HZR
Enriched GO Terms of Interacting Partners?
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