IL13RA2 and IL13

Number of citations of the paper that reports this interaction (PubMedID 11003391)
1

Data Source:
HPRD (in vivo, in vitro)

		IL13RA2	IL13
Description		interleukin 13 receptor subunit alpha 2	interleukin 13
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding	Cytokine Activity Interleukin-13 Receptor Binding Protein Binding
	Biological Process	Negative Regulation Of Immunoglobulin Production Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of Mast Cell Degranulation	Microglial Cell Activation Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Signal Transduction Regulation Of Proton Transport Positive Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of NAD(P)H Oxidase Activity Response To Nicotine Macrophage Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Ethanol Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Mechanical Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuron Death Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Pancreatic Stellate Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Interleukin-4 and Interleukin-13 signaling	Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling
Drugs		AER001	Cintredekin Besudotox Lebrikizumab
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Allergy ( 27182965) Alopecia areata ( 25608926) Asthma ( 31361310 31959851 34103634 20860503 32296059 31619474 29785011 29273806) Asthma (childhood onset) ( 24241537 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 23886662 25574825 26482879 23727859) Childhood asthma with severe exacerbations ( 33328473) Cutaneous psoriasis ( 26626624) Hodgkin's lymphoma ( 22286212 24920014) IgE levels ( 22075330) Inflammatory bowel disease ( 23128233) Lymphocyte counts ( 32888494) Psoriasis ( 25903422 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624) Rosacea symptom severity ( 29771307)
Interacting Genes		17 interacting genes: AKT1 BAG4 BRMS1 CASP8 EGFR ERBB2 ESR2 IGF1R IL13 IL4 IL4R NOTCH2 PALB2 PAX2 PIK3CA PLPP6 RB1CC1	5 interacting genes: IL13RA1 IL13RA2 IL4R PIK3R1 VCAM1
Entrez ID		3598	3596
HPRD ID		02132	00981
Ensembl ID		ENSG00000123496	ENSG00000169194
Uniprot IDs		Q14627	P35225
PDB IDs		3LB6	1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3LB6 4I77 4PS4 5E4E 5L6Y
Enriched GO Terms of Interacting Partners?
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