IL10 and KRTAP4-1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		IL10	KRTAP4-1
Description		interleukin 10	keratin associated protein 4-1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytosol Keratin Filament
	Molecular Function	Cytokine Activity Interleukin-10 Receptor Binding Protein Binding Growth Factor Activity Protein Dimerization Activity
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Response To Molecule Of Bacterial Origin Positive Regulation Of Immunoglobulin Production Negative Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of B Cell Apoptotic Process Signal Transduction Cytoplasmic Sequestering Of NF-kappaB Aging Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of Gene Expression Negative Regulation Of Autophagy Response To Activity Response To Inactivity Hemopoiesis B Cell Differentiation Leukocyte Chemotaxis Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of B Cell Proliferation Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Response To Insulin Negative Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Heterotypic Cell-cell Adhesion Response To Carbon Monoxide Cellular Response To Hepatocyte Growth Factor Stimulus Type 2 Immune Response B Cell Proliferation Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Isotype Switching Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Inflammatory Response Regulation Of Synapse Organization Negative Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of DNA-binding Transcription Factor Activity Response To Glucocorticoid Negative Regulation Of Cytokine Activity Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Estradiol Stimulus Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Endothelial Cell Apoptotic Process Liver Regeneration Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Response To Wounding Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Sensory Perception Of Pain Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Signaling Receptor Activity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CD163 mediating an anti-inflammatory response FCGR3A-mediated IL10 synthesis	Keratinization
Drugs		CRx-139 LLL-3348
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Behcet's disease ( 20622878 20622879 33393726) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28008999 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Pediatric autoimmune diseases ( 26301688) Systemic lupus erythematosus ( 26502338 28714469 19838195) Type 1 diabetes ( 21829393 25751624 19430480 30572963) Ulcerative colitis ( 19915572 28067908 26398853 20228798 20228799 18836448 21297633)
Interacting Genes		12 interacting genes: A2M GLRX3 IL10RA IL10RB KRTAP1-3 KRTAP10-8 KRTAP4-1 NBPF19 NOTCH2NLA PTPRC TNFSF4 YY1	26 interacting genes: CATSPER1 CRCT1 CREB5 DHRS1 FBXW5 GNE HOXA1 IL10 KRTAP5-6 KRTAP9-3 KRTAP9-8 LCE1B LCE1D LCE2D LCE3A LCE3C LCE3D LCE3E LCE5A NECTIN3 NPDC1 NUFIP2 OTX1 PSMA1 SMCP VASN
Entrez ID		3586	85285
HPRD ID		00495	13940
Ensembl ID		ENSG00000136634	ENSG00000198443
Uniprot IDs		P22301 Q6FGW4	Q9BYQ7
PDB IDs		1ILK 1INR 1J7V 1LK3 1Y6K 2H24 2ILK
Enriched GO Terms of Interacting Partners?
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