AQP1 and TMEM45B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		AQP1	TMEM45B
Description		aquaporin 1 (Colton blood group)	transmembrane protein 45B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Basal Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Symbiont-containing Vacuole Membrane Brush Border Membrane Nuclear Membrane Sarcolemma Apical Part Of Cell Extracellular Exosome	Integral Component Of Membrane
	Molecular Function	Intracellular CGMP-activated Cation Channel Activity Potassium Channel Activity Water Transmembrane Transporter Activity Protein Binding Ammonium Transmembrane Transporter Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Water Channel Activity Transmembrane Transporter Activity Nitric Oxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Identical Protein Binding	Protein Binding
	Biological Process	Renal Water Homeostasis Renal Water Transport Potassium Ion Transport Water Transport Cell Volume Homeostasis Hyperosmotic Response Cellular Water Homeostasis Carbon Dioxide Transport Ammonium Transport Glycerol Transport Cellular Homeostasis CGMP-mediated Signaling Lateral Ventricle Development Pancreatic Juice Secretion Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Cellular Response To UV Transepithelial Water Transport Carbon Dioxide Transmembrane Transport Odontogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Saliva Secretion Positive Regulation Of Fibroblast Proliferation Defense Response To Gram-negative Bacterium Multicellular Organismal Water Homeostasis Cellular Response To Hydrogen Peroxide Cellular Response To Inorganic Substance Cellular Response To Mechanical Stimulus Cellular Response To Copper Ion Cellular Response To Mercury Ion Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Potassium Ion Transmembrane Transport Ammonium Transmembrane Transport
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs		Acetazolamide B-nonylglucoside Mersalyl
Diseases
GWAS		Fractures ( 30598549) Heel bone mineral density ( 30598549 28869591) hemolysis of donated blood (osmotic) ( 34014839) Huntington's disease progression ( 28642124) Kidney stones ( 31729369) Nephrolithiasis ( 22396660) Systolic blood pressure ( 30224653) Total body bone mineral density ( 29304378) Triglyceride levels ( 34074324) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Breast cancer ( 22383897) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Obsessive-compulsive traits ( 33531474) Serum metabolite levels ( 33031748) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Type 2 diabetes ( 22238593)
Interacting Genes		134 interacting genes: ADAMTSL4 AMOT AQP6 BCL2L13 BEGAIN BHLHB9 BLZF1 BMF CCDC136 CCDC57 CCDC85B CCNDBP1 CD79A CDR2 CEP44 CLDN5 COMP CPLX4 CREB3 CRTAC1 CSRNP1 CYSRT1 EFEMP2 EPHB2 ESM1 EVI2B FAM161A FAM209A FNDC9 FOS FSD2 GET1 GJB5 GLI1 GOLGA2 GPR37L1 GPX8 IFT20 IGFBP6 IHO1 IKZF2 IKZF3 IL21R KCNK5 KCTD17 KCTD9 KHDRBS3 KIAA1958 KLHL26 KRT31 KRT33B KRT37 KRT40 KRTAP1-1 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-4 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE1A LDLRAD1 LDOC1 LIME1 LMNA LPXN LRRC59 MDFI MGST3 MID2 MIF4GD MKRN3 MRM1 MTUS2 MUC1 MYF5 NBPF19 NBPF22P NBPF6 NOTCH2NLA NUTM1 PGPEP1 PICK1 PLA2G10 PLSCR2 PPARA PRDM14 PRDM6 RBAK REL RGS17 RGS20 RIMBP3 RNF122 SAR1A SIAH1 SIVA1 SLC15A2 SLC39A2 SPDYA SPRED1 SPRED2 SPRY2 SPRY3 SPRYD7 SSMEM1 TCF4 TMEM237 TMEM38B TMEM45B TMEM80 TMPRSS2 TNK2 TNS2 TRAF1 TRAF2 TRIM23 TRIM37 TRIM41 TRIM42 TRIM7 TRIP6 TSC1 ZBTB39 ZIM2 ZNF16 ZNF398 ZNF792	41 interacting genes: ANKRD46 APOD APOL2 AQP1 BMP10 C3orf52 C4orf3 CACNG1 CDS2 CYB561D2 DOLK FAM3C FKBP8 GIMAP1 INSIG2 LAT NSG1 PLN PLP1 PLPP4 SEC22A SEC23A SMAGP SMIM1 SNORC SYNGR1 TINAG TMEM128 TMEM218 TMEM229B TMEM243 TMEM254 TMEM60 TMEM97 TNFRSF10C TREX1 TSPAN33 UBE2G2 UPK1B VAMP5 VKORC1
Entrez ID		358	120224
HPRD ID		00140	14020
Ensembl ID		ENSG00000240583	ENSG00000151715
Uniprot IDs		A0A024RA31 P29972	Q96B21
PDB IDs		1FQY 1H6I 1IH5 4CSK 6POJ
Enriched GO Terms of Interacting Partners?
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