CXCL8 and ZNF598

Number of citations of the paper that reports this interaction (PubMedID 30917308)
15

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		CXCL8	ZNF598
Description		C-X-C motif chemokine ligand 8	zinc finger protein 598, E3 ubiquitin ligase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytosol
	Molecular Function	Interleukin-8 Receptor Binding Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding	RNA Binding Protein Binding Ribosome Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Angiogenesis Response To Molecule Of Bacterial Origin Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Positive Regulation Of Cellular Biosynthetic Process Receptor Internalization Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Regulation Of Cell Cycle Negative Regulation Of Cell Adhesion Molecule Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Regulation Of Entry Of Bacterium Into Host Cell	Protein Monoubiquitination Protein Ubiquitination Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs		ABT-510 MDX-018 Rivanicline Tapinarof
Diseases
GWAS		Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566)
Interacting Genes		22 interacting genes: ACKR1 ARFGAP3 BAG6 CCL2 CCL4 CCL5 CCL8 CTSL CXCR1 CXCR2 EP300 ERBB2 GNAI2 IL12A MMP9 PF4 POMGNT1 SDC1 SGTA WASF1 ZFP36 ZNF598	5 interacting genes: CDA CXCL8 DBN1 GLIS2 UBE2D1
Entrez ID		3576	90850
HPRD ID		00909	11732
Ensembl ID		ENSG00000169429	ENSG00000167962
Uniprot IDs		A0A024RDA5 P10145	Q86UK7
PDB IDs		1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ 6LFM 6LFO 6N2U 6WZM
Enriched GO Terms of Interacting Partners?
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