IL2RG and IL4R

Number of citations of the paper that reports this interaction (PubMedID 8266076)
131

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		IL2RG	IL4R
Description		interleukin 2 receptor subunit gamma	interleukin 4 receptor
Image
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity	Interleukin-4 Receptor Activity Protein Binding
	Biological Process	Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Positive Regulation Of Phagocytosis	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Ovulation Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant
Pathways		Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling STAT3 nuclear events downstream of ALK signaling	Interleukin-4 and Interleukin-13 signaling
Drugs		Denileukin diftitox Aldesleukin Resatorvid	AER001 Dupilumab
Diseases
GWAS			Asthma ( 31361310 31959851 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		27 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 KRTAP10-8 KRTAP5-7 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2	28 interacting genes: ARIH2 CD40 DOK2 ERN2 FES HDGFL3 HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 NPIPB5 PRKCZ PTPN11 PTPN6 RACK1 RBBP6 SHC1 SLC20A1 SOCS5 STAT6
Entrez ID		3561	3566
HPRD ID		02391	00990
Ensembl ID		ENSG00000147168	ENSG00000077238
Uniprot IDs		P31785	B2RBY1 P24394
PDB IDs		1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL	1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL
Enriched GO Terms of Interacting Partners?
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