IL1A and IL1RAP

Number of citations of the paper that reports this interaction (PubMedID 9820540)
31

Data Source:
HPRD (in vitro)

		IL1A	IL1RAP
Description		interleukin 1 alpha	interleukin 1 receptor accessory protein
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane Glutamatergic Synapse
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Interleukin-1 Receptor Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Fever Generation Positive Regulation Of Cytokine Production Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Cellular Sodium Ion Homeostasis Apoptotic Process Inflammatory Response Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immature T Cell Proliferation In Thymus Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Response To Copper Ion Positive Regulation Of Protein Secretion Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cell Division Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Inflammatory Response Immune Response Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-33-mediated Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly
Pathways		Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Pyroptosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection
Drugs		Rilonacept
Diseases
GWAS		Dysmenorrheic pain severity ( 29855537) Endometriosis ( 20844546 28537267) Gestational age at birth (child effect) ( 31477735) Interleukin-1-receptor antagonist levels ( 22205395) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post-term birth ( 31477735) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)	Blood protein levels ( 30072576 29875488 28240269) Longitudinal change in brain amyloid plaque burden ( 26268530) Lung cancer ( 18385676) Waist circumference ( 20966902)
Interacting Genes		11 interacting genes: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP KPNA6 MEOX2 NDN NFKBIE S100A13	22 interacting genes: AP2M1 CCNI FXR1 IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP
Entrez ID		3552	3556
HPRD ID		00988	04021
Ensembl ID		ENSG00000115008	ENSG00000196083
Uniprot IDs		P01583	A8K6K4 Q9NPH3
PDB IDs		1ITA 2ILA 2KKI 2L5X 5UC6	3O4O 4DEP
Enriched GO Terms of Interacting Partners?
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