IGHM and HPR

Number of citations of the paper that reports this interaction (PubMedID 10085035)
56

Data Source:
HPRD (in vitro)

		IGHM	HPR
Description		immunoglobulin heavy constant mu	haptoglobin-related protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle	Extracellular Region Extracellular Space Spherical High-density Lipoprotein Particle Extracellular Exosome Blood Microparticle
	Molecular Function	Single-stranded DNA Binding Antigen Binding Phosphatidylcholine Binding Immunoglobulin Receptor Binding Peptidoglycan Binding	Serine-type Endopeptidase Activity Hemoglobin Binding
	Biological Process	Adaptive Immune Response Phagocytosis, Recognition Phagocytosis, Engulfment Complement Activation, Classical Pathway Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation	Acute Inflammatory Response Positive Regulation Of Cell Death Zymogen Activation
Pathways			Scavenging of heme from plasma
Drugs			Zinc Copper Zinc acetate
Diseases
GWAS		Systemic sclerosis ( 33069728)	Alanine aminotransferase levels ( 34315874) Apolipoprotein A1 levels ( 33730874) Aspartate aminotransferase levels ( 33547301 34315874) Blood protein levels ( 28240269) Cholesterol, total ( 24097068 28270201 25961943 20686565 26582766) Coronary artery disease ( 32469254 33020668) Hematocrit ( 32888494) LDL cholesterol ( 24097068 25961943 20686565 26582766) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731 33339817) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899) Triglyceride levels ( 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		19 interacting genes: APP CD22 CD79A CEP72 GADD45A GSK3B HPR HSPA5 JCHAIN MAP3K20 MAPKAPK3 PTK2 SH3GL2 SMN1 TK1 UBQLN4 UFD1 VPREB1 VPREB3	6 interacting genes: APOA1 DYNC1LI2 HSP90AA1 IGHM PSKH1 VKORC1
Entrez ID		3507	3250
HPRD ID		00912	00773
Ensembl ID		ENSG00000211899	ENSG00000261701
Uniprot IDs			P00739
PDB IDs
Enriched GO Terms of Interacting Partners?
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