ACADS and IRF7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ACADS	IRF7
Description		acyl-CoA dehydrogenase short chain	interferon regulatory factor 7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Centrosome	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane
	Molecular Function	Acyl-CoA Dehydrogenase Activity Butyryl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Butyrate Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Response To Virus Immunoglobulin Mediated Immune Response Establishment Of Viral Latency Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Innate Immune Response Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Defense Response To Virus Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process
Pathways		Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA	DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Drugs		NADH Acetoacetyl-CoA Flavin adenine dinucleotide
Diseases
GWAS		Allergic rhinitis ( 30013184) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood metabolite levels ( 24816252) Mean corpuscular volume ( 29403010) Metabolic traits ( 21886157) Metabolite levels ( 31628463 20037589) Red blood cell count ( 27863252) Red cell distribution width ( 27863252) Refractive error ( 32231278) Schizophrenia ( 30285260) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 33031748 23093944) Serum metabolite ratios in chronic kidney disease ( 29545352) Smoking status (ever vs never smokers) ( 30643258) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolites (H-NMR features) ( 24586186)	Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989)
Interacting Genes		2 interacting genes: APAF1 IRF7	28 interacting genes: ACADS AIP ARAF CCDC47 CDK4 CREBBP EP300 GCLM INSR IRAK1 IRF3 KAT2A KAT2B LTN1 MAVS MYD88 PALD1 PIAS4 SOCS1 SOCS3 TBK1 TICAM1 TICAM2 TLK2 TP53 TRAF6 TRIM28 TRMT61B
Entrez ID		35	3665
HPRD ID		06053	05441
Ensembl ID		ENSG00000122971	ENSG00000185507
Uniprot IDs		B4DUH1 E5KSD5 E9PE82 P16219	A0A024RCA2 B4E1B1 M9RSF4 Q92985
PDB IDs		2VIG	2O61
Enriched GO Terms of Interacting Partners?
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