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IGFBP5 and ERGIC3
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
IGFBP5
ERGIC3
Description
insulin like growth factor binding protein 5
ERGIC and golgi 3
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Insulin-like Growth Factor Binding Protein Complex
Insulin-like Growth Factor Ternary Complex
Endoplasmic Reticulum
Membrane
COPII-coated ER To Golgi Transport Vesicle
Integral Component Of Golgi Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Molecular Function
Fibronectin Binding
Protein Binding
Insulin-like Growth Factor I Binding
Insulin-like Growth Factor II Binding
Protein Binding
Biological Process
Regulation Of Cell Growth
Osteoblast Differentiation
Signal Transduction
Female Pregnancy
Aging
Negative Regulation Of Smooth Muscle Cell Migration
Negative Regulation Of Translation
Negative Regulation Of Cell Migration
Hair Follicle Morphogenesis
Intracellular Signal Transduction
Glucose Homeostasis
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Type B Pancreatic Cell Proliferation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Growth
Lung Alveolus Development
Negative Regulation Of Smooth Muscle Cell Proliferation
Striated Muscle Cell Differentiation
Positive Regulation Of Protein Kinase B Signaling
Mammary Gland Involution
Response To Growth Hormone
Cellular Response To CAMP
Cellular Response To Organic Cyclic Compound
Negative Regulation Of Muscle Tissue Development
Negative Regulation Of Skeletal Muscle Hypertrophy
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Pathways
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Drugs
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Breast cancer (
29059683
)
Creatinine levels (
29403010
)
Estimated glomerular filtration rate (
30604766
)
FEV1 (
30804560
)
Glomerular filtration rate (
27588450
29403010
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Height (
31562340
)
Hypothyroidism (
27182965
)
Lung function (FEV1/FVC) (
30804560
)
Metabolite levels (
23823483
)
Mitral valve prolapse (
26301497
)
Pulse pressure (
27841878
)
Serum thyroid-stimulating hormone levels (
25436638
)
Thyroid hormone levels (
23408906
)
Thyroid stimulating hormone levels (
32769997
)
Visceral fat (
22589738
)
Apolipoprotein B levels (
32203549
)
Brain morphology (MOSTest) (
32665545
)
Cholesterol, total (
24097068
25961943
20686565
)
Height (
28552196
)
Hip circumference adjusted for BMI (
28552196
34021172
)
LDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Schizophrenia (
28991256
)
Total cholesterol levels (
28334899
30275531
)
Triglycerides (
25961943
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
93 interacting genes:
ABHD4
ADAM12
AHNAK2
AMIGO1
ANKS6
APH1A
AQP2
AQP6
AQP9
ASGR1
BAG6
BSND
CD53
CERS4
CHODL
CLDN2
CLDN20
CLDN6
CLDN7
CLDN9
CLEC17A
CREB3
CSDE1
CXCR1
ELOVL5
ERGIC3
F2
FAM209A
FCRL3
FHL1
FHL2
FN1
FNDC9
GJA5
GJA8
GJB3
GJB5
GOLM1
GPR151
GPR152
GPR37L1
GPR42
GPRC5D
GPX8
HSD17B13
IGF1
IGF2
IGFALS
KCNK5
KIAA2013
KPNB1
LAPTM4B
LAYN
LDLRAD1
LHFPL1
LMNA
LTBP1
MFF
MFSD5
MRPS18B
MS4A3
MS4A7
NCAPH2
PAPPA2
PDZK1IP1
PNO1
PROKR2
RASSF1
RHCG
SERPINE1
SLC10A6
SLC13A4
SLC38A1
SLC41A2
SLC41A3
SPAG4
SPP1
SYNE4
TF
THAP4
THBS1
TLCD4
TMEM106A
TMEM106C
TMEM179B
TMEM237
TMEM45A
TMEM52B
TMPRSS2
TMX2
TSPAN12
TSPO2
VTN
206 interacting genes:
ABHD16A
AGPAT4
AGTRAP
AIG1
ALG10
AOC2
APOC3
APOD
AQP10
AQP2
AQP3
ASGR1
BCL2L1
BET1
BIK
BNIP3
BTN2A2
BUD31
C14orf180
C2
C3orf52
C4orf3
CCDC167
CCR2
CCR4
CCR8
CD207
CD302
CD81
CDIPT
CDS2
CFHR5
CHRM4
CIAO2A
CLCA4
CLDN19
CLDN8
CLDND2
CMTM5
CNIH1
CNIH3
COL4A5
COX20
CTSA
CTXN3
CXorf66
CYB561
CYB561D2
CYBC1
CYP4F2
DEFB103A
DEFB103B
EBP
EMC6
EMP1
EMP3
ENTPD3
ERGIC1
EXTL1
F2RL1
FA2H
FAM3C
FAXDC2
FETUB
FIS1
FKBP8
FXYD2
FXYD3
FXYD6
GAST
GIMAP1
GIMAP5
GJB2
GPM6B
GPR151
GPR35
GPR37
GYPA
HHATL
HMOX1
HMOX2
IFITM3
IGFBP5
ITGAM
JAGN1
KCNK1
LHFPL5
LPAR3
LPCAT2
MARCHF2
MARCHF5
MFF
MFSD6
MIP
MS4A13
MYADM
NDRG4
NDUFB6
NEU1
NINJ2
NKG7
NRG4
NRM
NSG1
OGT
ORMDL1
ORMDL3
PAQR5
PAQR7
PEX11G
PEX16
PGAP2
PLLP
PLP1
PLPP4
PMP22
POFUT1
POMGNT1
RFT1
RHAG
RTP2
RUSF1
SCARB2
SCD
SEC22B
SEC23A
SELENOK
SERP2
SFXN5
SLC13A3
SLC1A1
SLC29A2
SLC35A1
SLC35A4
SLC35B2
SLC35B4
SLC38A7
SLC41A1
SLC41A2
SLC49A3
SMAGP
SMCO4
SMIM1
SMIM3
SNORC
SPN
STATH
STX12
STX1B
STX3
STX8
SYNGR1
SYNJ2BP
SYS1
TAP1
TECR
TF
THBD
TM4SF4
TMEM100
TMEM107
TMEM109
TMEM120B
TMEM128
TMEM141
TMEM14A
TMEM14B
TMEM179B
TMEM203
TMEM218
TMEM222
TMEM229B
TMEM243
TMEM42
TMEM60
TMEM65
TMEM86A
TMEM86B
TMEM97
TMUB2
TNFRSF10C
TOMM6
TRAM1L1
TRARG1
TRIM32
TSPAN33
TSPO2
UBIAD1
UNC50
UNC93B1
VAMP1
VAMP2
VAMP3
VAMP4
VKORC1L1
VMP1
VSTM1
VTI1B
YIF1A
YIPF1
YIPF2
YIPF4
YIPF6
ZDHHC15
ZDHHC21
ZFPL1
Entrez ID
3488
51614
HPRD ID
00901
15306
Ensembl ID
ENSG00000115461
ENSG00000125991
Uniprot IDs
P24593
A2TJK5
Q9Y282
PDB IDs
1BOE
1H59
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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