HSD17B13 and MARCHF5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HSD17B13	MARCHF5
Description		hydroxysteroid 17-beta dehydrogenase 13	membrane associated ring-CH-type finger 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lipid Droplet Cytosol	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Molecular_function Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Protein Binding Zinc Ion Binding GTPase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Lipid Biosynthetic Process	Protein Polyubiquitination Protein Autoubiquitination Protein Localization To Mitochondrion Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission Negative Regulation Of Cell Aging
Pathways		Lipid particle organization
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bulimia nervosa ( 23568457) Cirrhosis (alcohol related) ( 32853455) Cirrhosis (multi-trait analysis) ( 33310085) Liver enzyme levels (alanine transaminase) ( 22001757) Nonalcoholic steatohepatitis ( 32298765) Platelet count ( 22139419) Rosacea symptom severity ( 29771307) Triglyceride levels ( 31928498)
Interacting Genes		118 interacting genes: ABHD16A ADGRE2 AGPAT3 AGPAT4 AGTRAP AIG1 ANKRD46 AOC3 APOA2 ARL6IP1 ATP6V0C BBC3 BRICD5 C3orf52 CACNG1 CALHM6 CCDC167 CDIPT CLDN10 CLDN19 CLDN4 CLDND2 CMTM5 CMTM7 CYB5R3 CYBC1 CYP4F2 DIABLO EBP ECPAS FATE1 FAXDC2 FETUB GJB2 GOLM1 GOSR2 GYPB HSD3B7 IGFBP5 INSIG2 ITGAM JAGN1 LPCAT2 LRAT MARCHF5 MFSD5 MGLL MIEF2 MMP14 MOSPD3 MS4A1 NAPB NAT8 NRM ORMDL3 PBX3 PLIN3 PLN PLP2 PNLIPRP1 PTPN9 RABAC1 REEP6 RHOU RPRM RUSF1 SACM1L SCAMP5 SCARF1 SCD SEC22B SERP1 SFT2D2 SFXN1 SFXN2 SFXN3 SLC25A46 SLC30A3 SLC35B4 SLC35E4 SMIM1 SNORC SPG21 ST6GAL2 STRIT1 STX5 STX7 TBRG4 TF THSD7A TIMM23 TIMMDC1 TMEM100 TMEM120A TMEM140 TMEM14C TMEM167B TMEM19 TMEM203 TMEM222 TMEM229B TMEM243 TMEM255B TMEM31 TMEM42 TMEM60 TMEM86B TMEM97 TMX2 TPRG1 TREX1 UBXN8 UNC50 VAMP2 VAPA VAPB YIPF2 YIPF4	39 interacting genes: AKTIP ANKS6 AQP6 BIK BNIP1 CGRRF1 CREB3 ERGIC3 FATE1 FIS1 FUNDC1 GPX8 HSD17B13 MANBAL MAP1B MFN2 ODF4 PTPN5 RTN4IP1 SAR1A SCD SGPL1 SOD1 STMN4 TANK TIMMDC1 TMEM139 TMEM14B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN YIF1A
Entrez ID		345275	54708
HPRD ID		18023	07909
Ensembl ID		ENSG00000170509	ENSG00000198060
Uniprot IDs		Q7Z5P4	Q9NX47
PDB IDs
Enriched GO Terms of Interacting Partners?
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