NHSL2 and ABI1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		NHSL2	ABI1
Description		NHS like 2	abl interactor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Intracellular Anatomical Structure Nucleus Endoplasmic Reticulum Cytosol Cytoskeleton Postsynaptic Density Lamellipodium Growth Cone SCAR Complex Filopodium Tip Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Signaling Adaptor Activity Cadherin Binding
	Biological Process	Cell Differentiation	Somitogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Polymerization Or Depolymerization Negative Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation Megakaryocyte Development Dendrite Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Lamellipodium Morphogenesis
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		27 interacting genes: ABI1 ABI2 ABI3 ARID4B ATXN1 BTRC CLIC1 CTTN DYNLT1 GORASP2 HSF2BP INCA1 MAPK9 MTUS2 MYO15B NCK1 NCK2 PIH1D2 PLK1 PPP1R13B SH3RF1 SORBS3 TFCP2 TP53BP2 TRAF2 YWHAG YWHAH	69 interacting genes: ABI2 ABL1 APBB1 C22orf15 CACNA1A CCDC57 CCHCR1 CUL2 CYFIP2 DST DTNB EIF3H ENAH ENKD1 EPS8 EPS8L1 EVL FAM124B FBXL19 FHL2 FXR1 GAS7 HHEX HNRNPK HOMER1 HOMER3 HSPA8 KIAA0408 KIAA1217 KTN1 LMO1 MAB21L2 MINK1 MRFAP1 MRFAP1L1 NCK1 NCK2 NCKAP1 NEB NFASC NHSL2 NIN OGT PAK2 PCM1 PRKAA2 PRPF40A RBM15 RCOR3 SHANK3 SMARCD1 SORBS1 SORBS2 SOS1 SOS2 SPTA1 SPTAN1 SRP68 SRRM1 SYNE2 TCERG1 TLN1 TRIP10 TSC1 TTC23 VARS2 VASP WASF1 WASF2
Entrez ID		340527	10006
HPRD ID		15001	04336
Ensembl ID		ENSG00000204131	ENSG00000136754
Uniprot IDs		Q5HYW2	A0A0A0MRT6 B6VEX3 B6VEX4 B6VEX5 Q8IZP0
PDB IDs
Enriched GO Terms of Interacting Partners?
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