KRTAP6-3 and GATA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KRTAP6-3	GATA2
Description		keratin associated protein 6-3	GATA binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm
	Molecular Function		RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Keratinization	Negative Regulation Of Transcription By RNA Polymerase II Urogenital System Development Cell Fate Determination Neuron Migration Embryonic Placenta Development Regulation Of Transcription By RNA Polymerase II Phagocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Primitive Erythrocyte Differentiation Ventral Spinal Cord Interneuron Differentiation Cell Differentiation In Hindbrain Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Pituitary Gland Development Response To Lipid Somatic Stem Cell Population Maintenance Regulation Of Histone Acetylation Eosinophil Fate Commitment Inner Ear Morphogenesis Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Phagocytosis Positive Regulation Of Phagocytosis, Engulfment Definitive Hemopoiesis Semicircular Canal Development Vascular Wound Healing Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cochlea Development GABAergic Neuron Differentiation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Forebrain Neuron Differentiation
Pathways			RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Basophil count ( 28031487) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) Eosinophil counts ( 19198610) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Preterm birth (maternal effect) ( 28877031) Prostate cancer ( 31562322) Pulse pressure ( 28135244 27841878 30578418) Systolic blood pressure ( 27841878) White blood cell count ( 21738480) White blood cell count (basophil) ( 28158719) White blood cell count (eosinophil) ( 28158719) White blood cell types ( 21738478)
Interacting Genes		159 interacting genes: ADAMTSL4 AGXT ARID5A ARMC7 ATPAF2 AUTS2 BAG4 BEX2 BSCL2 C11orf87 CAMK2A CAMK2B CAMK2G CARHSP1 CCDC120 CCDC24 CCER1 CELF5 CHRD CLCNKA CNNM3 COL8A1 CREB5 CRY2 CTSZ CYSRT1 DALRD3 DHRS1 DMRT3 FADS6 FAM214B FAM83A FBXW5 FCHO1 FOXD2 FOXD4L1 GATA2 GATA3 GLYCTK GNE GPS2 HAPLN2 HHEX HOXA1 HOXB5 HOXB9 HOXC8 HR HYAL2 ILF2 INCA1 INPP5D ITGB4 KANK2 KPRP KRT20 KRTAP11-1 KRTAP12-2 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP4-4 KRTAP6-1 KRTAP6-2 LAGE3 LCE1B LCE1C LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE3C LCE3D LCE3E LCE5A LGALS9 LNX1 MAGED1 MAPK1IP1L MAPKBP1 MBD3L2 MED25 MEIS2 MEOX2 MGAT5B NODAL NOTO NR4A3 OLIG3 OTX1 OXER1 P4HB PATZ1 PCDHB14 PGAP6 PHETA1 PHLDA1 PIGS PITX1 PLSCR4 POU4F2 POU4F3 PPP1R32 PPP1R37 PRMT8 PROP1 PRPF31 PRR13 PRR3 PRR35 PSMA1 PVR RAB3IL1 RAD54L2 RASD1 RHBDL1 RUNX1T1 SAMD7 SEMA4C SH3KBP1 SLC15A2 SLC22A5 SMARCC1 SMARCE1 SMCP SNRPB SNRPC SNX18 STK16 STRA6 TAOK2 TBX2 TBX6 TCAF1 TCF7L2 TEKT4 TENT2 TEX45 TFAP2D TLE5 TLX3 TNIP1 TNS2 TSPYL6 TYK2 VASN VENTX VSTM4 WDR25 ZBTB32 ZIC1 ZNF414 ZNF497 ZNF575 ZNF79	46 interacting genes: ADAMTSL4 AKT1 CDK1 CEBPA CYSRT1 EP300 FBXW7 FHL3 GOLGA2 HDAC3 HDAC5 HHEX JUN KAT2A KRT40 KRTAP10-3 KRTAP10-9 KRTAP11-1 KRTAP13-3 KRTAP21-2 KRTAP3-1 KRTAP6-3 KRTAP7-1 KRTAP8-1 LMO2 MAPK1 MDFI MSX2 NOTCH2NLA PML POU1F1 POU2AF1 PRR20A PSMA3 RARA RBPMS RXRA SMAD4 SPI1 STAT3 TAL1 TRAF1 TRIM23 ZBTB16 ZBTB32 ZFPM1
Entrez ID		337968	2624
HPRD ID		11220	00673
Ensembl ID		ENSG00000212938	ENSG00000179348
Uniprot IDs			P23769
PDB IDs			5O9B
Enriched GO Terms of Interacting Partners?
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