APOA2 and PDZK1IP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		APOA2	PDZK1IP1
Description		apolipoprotein A2	PDZK1 interacting protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Early Endosome Endoplasmic Reticulum Lumen Cytosol Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Exosome Blood Microparticle	Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Heat Shock Protein Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity	Protein Binding
	Biological Process	Acute Inflammatory Response Negative Regulation Of Cytokine Production Involved In Immune Response Triglyceride Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Xenobiotic Stimulus Response To Glucose Positive Regulation Of Cholesterol Esterification Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein Oxidation Peptidyl-methionine Modification Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Animal Organ Regeneration Regulation Of Protein Stability Negative Regulation Of Cholesterol Transport Positive Regulation Of Interleukin-8 Production Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Response To Estrogen Reverse Cholesterol Transport Diacylglycerol Catabolic Process Positive Regulation Of Phagocytosis Protein Stabilization Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Response To Glucocorticoid Negative Regulation Of Lipase Activity Negative Regulation Of Cholesterol Import Negative Regulation Of Cholesterol Transporter Activity Intermembrane Lipid Transfer
Pathways		PPARA activates gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs		Zinc Copper Zinc acetate
Diseases
GWAS			Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		30 interacting genes: ABCA13 APOC1 APOD APOF AQP6 C4A CATSPER1 CIAO2A CREB3 CYBC1 GET1 GJA8 HSD17B13 KIR2DL3 LMNA MUC1 NAXE NDRG1 PANX1 PDZK1IP1 PLTP PSCA SCARB1 SLC7A1 SSMEM1 STOM TMEM45A TMEM82 TREM2 VKORC1	77 interacting genes: AGR3 AIG1 APOA2 APOD AQP2 AQP6 ARL13B ASGR1 C14orf180 C2CD2L CD81 CES1 CLDN19 COPS6 CYB5B CYBC1 EMC6 ERG28 FAM3C FCER1G GALNT15 GAST GIMAP5 GRM2 GYPA HMOX1 ICMT IGFBP5 JAGN1 LEPROTL1 LHFPL5 MIP MYADM MYADML2 NSG1 NUMB PDZK1 PEX16 PGAP2 PLP2 PLPP4 PLPP6 PMP22 RPRM RTP2 SDCBP SFTPC SFXN2 SLC22A1 SLC22A2 SLC35B1 SLC35B4 STRIT1 STX12 THBD TMEM101 TMEM107 TMEM109 TMEM11 TMEM140 TMEM14A TMEM14B TMEM14C TMEM203 TMEM39B TMEM65 TMEM86A TMEM97 TNFRSF10C TRARG1 TRIM54 TSPO2 UPK1B UTP14A VAMP3 YIPF6 ZDHHC17
Entrez ID		336	10158
HPRD ID		00129	06211
Ensembl ID		ENSG00000158874	ENSG00000162366
Uniprot IDs		P02652	Q13113
PDB IDs
Enriched GO Terms of Interacting Partners?
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