HSPG2 and ITGB1

Number of citations of the paper that reports this interaction (PubMedID 9431988)
44

Data Source:
HPRD (in vitro)

		HSPG2	ITGB1
Description		heparan sulfate proteoglycan 2	integrin subunit beta 1
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Plasma Membrane Protein Complex	Ruffle Cytoplasm Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Endosome Membrane Intercalated Disc Membrane Lamellipodium Filopodium Neuromuscular Junction Cleavage Furrow Ruffle Membrane Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha4-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Myelin Sheath Abaxonal Region Sarcolemma Melanosome Dendritic Spine Receptor Complex Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Synaptic Membrane
	Molecular Function	Amyloid-beta Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Low-density Lipoprotein Particle Receptor Binding	Virus Receptor Activity Fibronectin Binding Protease Binding Actin Binding Integrin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Laminin Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Collagen Binding Involved In Cell-matrix Adhesion Protein Tyrosine Kinase Binding
	Biological Process	Angiogenesis Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Brain Development Animal Organ Morphogenesis Tissue Development Negative Regulation Of Angiogenesis Cell Differentiation Circulatory System Development	G1/S Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation In Utero Embryonic Development Cell Fate Specification Cell Migration Involved In Sprouting Angiogenesis Phagocytosis Cellular Defense Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Germ Cell Migration Visual Learning Regulation Of Collagen Catabolic Process Positive Regulation Of Fibroblast Migration Cell Migration Formation Of Radial Glial Scaffolds CD40 Signaling Pathway Cell Projection Organization Lamellipodium Assembly B Cell Differentiation Positive Regulation Of Cell Migration Cell-substrate Adhesion Receptor Internalization Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Maintenance Of Blood-brain Barrier Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of GTPase Activity Sarcomere Organization Negative Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Viral Entry Into Host Cell Mesodermal Cell Differentiation Axon Extension Dendrite Morphogenesis Leukocyte Tethering Or Rolling Regulation Of Cell Cycle Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Cardiac Muscle Cell Differentiation Cellular Response To Low-density Lipoprotein Particle Stimulus Basement Membrane Organization Positive Regulation Of Wound Healing Regulation Of Spontaneous Synaptic Transmission Reactive Gliosis Regulation Of Inward Rectifier Potassium Channel Activity Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Signaling Receptor Activity Negative Regulation Of Anoikis
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport Amyloid fiber formation	Elastic fibre formation Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Basigin interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans Other semaphorin interactions Signal transduction by L1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions CHL1 interactions RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen MET activates PTK2 signaling MET interacts with TNS proteins RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle HCMV Early Events Potential therapeutics for SARS
Drugs		Palifermin	Antithymocyte immunoglobulin (rabbit) MK-0668
Diseases
GWAS		Atrial fibrillation ( 30061737) Cerebral microbleeds (lobar) ( 32913026) Height ( 28552196) PR interval ( 32439900)	Depression (quantitative trait) ( 20800221) Suicide in bipolar disorder ( 25917933)
Interacting Genes		33 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN HSP90AA1 ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TCAP TTR UBC VWA1	82 interacting genes: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD36 CD46 CD82 CD9 CD93 CRKL DAG1 DOK1 EFNA4 EGFR ENO1 EPS8 FBLN1 FBXO2 FERMT1 FERMT2 FERMT3 FHL2 FLNA FLNB FLT4 FN1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LAMTOR5 LGALS1 LGALS3BP LGALS8 MAP4K4 MET NCKIPSD NF2 NGF NME1 NMRK2 PDHB PIP5K1C PLAUR PRKCA PRKCE PTK2 PXN RAB25 RACK1 SLC3A2 SPP1 TGFBR1 TGM2 TGOLN2 TIMP2 TLN1 TNC TSPAN4 UPF2 VCAM1 VCAN YWHAB ZEB1 ZNF33A
Entrez ID		3339	3688
HPRD ID		00804	00628
Ensembl ID		ENSG00000142798	ENSG00000150093
Uniprot IDs		P98160	P05556
PDB IDs		3SH4 3SH5	1K11 1LHA 3G9W 3T9K 3VI3 3VI4 4DX9 4WJK 4WK0 4WK2 4WK4
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?