HP and HBB

Number of citations of the paper that reports this interaction (PubMedID 24981860)
22

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		HP	HBB
Description		haptoglobin	hemoglobin subunit beta
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen	Extracellular Region Extracellular Space Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding	Peroxidase Activity Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Hemoglobin Binding Haptoglobin Binding Hemoglobin Alpha Binding Organic Acid Binding Metal Ion Binding
	Biological Process	Acute Inflammatory Response Defense Response Acute-phase Response Positive Regulation Of Cell Death Zymogen Activation Response To Hydrogen Peroxide Defense Response To Bacterium Negative Regulation Of Oxidoreductase Activity Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process	Regulation Of Blood Pressure Positive Regulation Of Cell Death Oxygen Transport Nitric Oxide Transport Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Renal Absorption Platelet Aggregation Cellular Oxidant Detoxification
Pathways		Scavenging of heme from plasma Neutrophil degranulation	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Scavenging of heme from plasma Neutrophil degranulation Chaperone Mediated Autophagy Late endosomal microautophagy Cytoprotection by HMOX1 Heme signaling Factors involved in megakaryocyte development and platelet production
Drugs		Zinc chloride Zinc sulfate, unspecified form	Iron Dextran Zinc 4-Carboxycinnamic Acid Pentaerythritol tetranitrate 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine Sebacic acid 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID 2,6-dicarboxynaphthalene Efaproxiral Trimesic acid Nitrous acid Copper Ferric pyrophosphate Sodium ferric gluconate complex Ferric pyrophosphate citrate Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Apolipoprotein A1 levels ( 33730874) Blood protein levels ( 29875488 28240269) Cholesterol, total ( 25961943 20686565) Haptoglobin levels ( 22403646) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) LDL cholesterol ( 25961943 20686565) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Morning person ( 30696823) Parental lifespan ( 30642433) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010 33339817) Urinary haptoglobin levels in type 2 diabetes ( 29572449)	Blood cell traits (multivariate analysis) ( 31080455) Estimated glomerular filtration rate ( 33783510) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) F-cell distribution ( 17767159) Fetal hemoglobin levels ( 18245381) Glycated hemoglobin levels ( 34059833 31213470) HbA2 levels ( 23043469) Hematocrit ( 28453575 31869403) Hematology traits ( 23263863) Hemoglobin A1c levels ( 31217584) Hemoglobin levels ( 26366553 31869403) hemolysis of donated blood (osmotic) ( 34014839) Inflammatory biomarkers ( 22291609) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Low density lipoprotein cholesterol levels ( 33339817) Malaria ( 22895189 23717212 19465909 31844061) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 23263863 28453575) Mean corpuscular volume ( 32888494 28453575) Red cell distribution width ( 31080455) Severe malaria ( 29381699) Total cholesterol levels ( 33339817) Urate levels ( 31578528) Urinary albumin-to-creatinine ratio ( 27650483 31511532 32600054)
Interacting Genes		21 interacting genes: ADAMTS4 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB HSP90AA1 ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL	12 interacting genes: HBA1 HBA2 HBG2 HBM HBQ1 HBZ HP LINC02582 PABPC1 SELENOT UCHL5 UPF3B
Entrez ID		3240	3043
HPRD ID		00772	00786
Ensembl ID		ENSG00000257017	ENSG00000244734
Uniprot IDs		A0A0C4DGL8 P00738 Q6PEJ8	D9YZU5 P68871
PDB IDs		4WJG 4X0L 5HU6 6TB2	1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CBL 1CBM 1CH4 1CLS 1CMY 1COH 1DKE 1DXT 1DXU 1DXV 1FN3 1G9V 1GBU 1GBV 1GLI 1GZX 1HAB 1HAC 1HBA 1HBB 1HBS 1HCO 1HDB 1HGA 1HGB 1HGC 1HHO 1IRD 1J3Y 1J3Z 1J40 1J41 1J7S 1J7W 1J7Y 1JY7 1K0Y 1K1K 1KD2 1LFL 1LFQ 1LFT 1LFV 1LFY 1LFZ 1LJW 1M9P 1MKO 1NEJ 1NIH 1NQP 1O1I 1O1J 1O1K 1O1L 1O1M 1O1N 1O1O 1O1P 1QI8 1QSH 1QSI 1QXD 1QXE 1R1X 1R1Y 1RPS 1RQ3 1RQ4 1RQA 1RVW 1SDK 1SDL 1THB 1UIW 1VWT 1XXT 1XY0 1XYE 1XZ2 1XZ4 1XZ5 1XZ7 1XZU 1XZV 1Y09 1Y0A 1Y0C 1Y0D 1Y0T 1Y0W 1Y22 1Y2Z 1Y31 1Y35 1Y45 1Y46 1Y4B 1Y4F 1Y4G 1Y4P 1Y4Q 1Y4R 1Y4V 1Y5F 1Y5J 1Y5K 1Y7C 1Y7D 1Y7G 1Y7Z 1Y83 1Y85 1Y8W 1YDZ 1YE0 1YE1 1YE2 1YEN 1YEO 1YEQ 1YEU 1YEV 1YFF 1YG5 1YGD 1YGF 1YH9 1YHE 1YHR 1YIE 1YIH 1YVQ 1YVT 1YZI 2D5Z 2D60 2DN1 2DN2 2DN3 2DXM 2H35 2HBC 2HBD 2HBE 2HBF 2HBS 2HCO 2HHB 2HHD 2HHE 2M6Z 2W6V 2W72 2YRS 3B75 3D17 3D7O 3DUT 3HHB 3HXN 3IC0 3IC2 3KMF 3NL7 3NMM 3ODQ 3ONZ 3OO4 3OO5 3P5Q 3QJB 3QJC 3QJD 3QJE 3R5I 3S65 3S66 3SZK 3W4U 3WCP 3WHM 4FC3 4HHB 4IJ2 4L7Y 4M4A 4M4B 4MQC 4MQG 4MQH 4MQI 4N7N 4N7O 4N7P 4N8T 4NI0 4NI1 4ROL 4ROM 4WJG 4X0L 4XS0 5E29 5E6E 5E83 5EE4 5HU6 5HY8 5JDO 5KDQ 5KSI 5KSJ 5NI1 5SW7 5U3I 5UCU 5UFJ 5URC 5VMM 5WOG 5WOH 5X2R 5X2S 5X2T 5X2U 6BB5 6BNR 6BWP 6BWU 6DI4 6FQF 6HAL 6HBW 6HK2 6KA9 6KAE 6KAH 6KAI 6KAO 6KAP 6KAQ 6KAR 6KAS 6KAT 6KAU 6KAV 6KYE 6L5V 6L5W 6L5X 6L5Y 6LCW 6LCX 6NBC 6NBD 6NQ5 6TB2 6XD9 6XDT 6XE7 7AET 7AEU 7AEV 7JJQ 7JXZ 7JY0 7JY1 7JY3
Enriched GO Terms of Interacting Partners?
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