APBB1 and TSHZ2

Number of citations of the paper that reports this interaction (PubMedID 19343227)
19

Data Source:
BioGRID (pull down)

		APBB1	TSHZ2
Description		amyloid beta precursor protein binding family B member 1	teashirt zinc finger homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Speck Lamellipodium Growth Cone Protein-containing Complex Presynaptic Membrane Neuronal Cell Body Dendritic Spine Main Axon Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Growth Cone Lamellipodium Growth Cone Filopodium	Chromatin Nucleus
	Molecular Function	Amyloid-beta Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Histone Binding Protein-containing Complex Binding Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Proline-rich Region Binding DNA-binding Transcription Factor Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Regulation Of Transcription, DNA-templated Apoptotic Process Smooth Muscle Contraction Cellular Response To DNA Damage Stimulus Signal Transduction Axonogenesis Response To Iron Ion Positive Regulation Of Neuron Projection Development Positive Regulation Of Apoptotic Process Histone H4 Acetylation Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion Negative Regulation Of Cell Cycle G1/S Phase Transition	Regulation Of Transcription By RNA Polymerase II
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Malaria ( 31844061)	Adventurousness ( 30643258) Age at first sexual intercourse ( 34211149) Alcohol consumption (max-drinks) ( 29460428) Apolipoprotein A1 levels ( 32203549) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Body shape index ( 34021172) Coronary artery aneurysm in Kawasaki disease ( 27171184) Crohn's disease ( 32581322) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) General risk tolerance (MTAG) ( 30643258) Hemoglobin ( 19862010) Hip index ( 34021172) Parkinson's disease ( 26227905) Spatial memory ( 31596458) Triglyceride levels ( 32203549) Triglyceride levels x loop diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969) Type 2 diabetes (age of onset) ( 28060188) Urinary metabolite levels in chronic kidney disease ( 29545352) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		69 interacting genes: ABI1 ABL1 ANXA1 APLP1 APLP2 APP ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRKAR2A PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ TENM1 TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1	21 interacting genes: APBB1 BACH2 CCDC57 CCDC88B CNTROB COG3 CRACR2B GIGYF1 GOLGA2 GRIPAP1 MCC PHAF1 PIBF1 PNMA1 RABEP1 RINT1 SPTA1 TFIP11 TRAF1 TRAF2 UBE2I
Entrez ID		322	128553
HPRD ID		04087	10730
Ensembl ID		ENSG00000166313	ENSG00000182463
Uniprot IDs		B7Z4M9 O00213	Q9NRE2
PDB IDs		2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH
Enriched GO Terms of Interacting Partners?
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