NUDT2 and MCM6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		NUDT2	MCM6
Description		nudix hydrolase 2	minichromosome maintenance complex component 6
Image
GO Annotations	Cellular Component	Mitochondrial Matrix	Chromosome, Telomeric Region Nucleus Nucleoplasm MCM Complex CMG Complex
	Molecular Function	Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity Protein Binding GTP Binding Bis(5'-nucleosyl)-tetraphosphatase (symmetrical) Activity	DNA Helicase Activity Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Identical Protein Binding Single-stranded 3'-5' DNA Helicase Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process AMP Biosynthetic Process ATP Biosynthetic Process Apoptotic Process Cellular Response To Oxidative Stress	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Mitotic DNA Replication
Pathways		Detoxification of Reactive Oxygen Species	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Fruit consumption ( 32066663)	Aspartate aminotransferase levels ( 33547301) Body fat percentage and LDL-C (pairwise) ( 33619380) Body mass index ( 25673413) Body mass index and LDL-C (pairwise) ( 33619380) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		3 interacting genes: DDIT4L MCM6 PLEKHF2	37 interacting genes: C2CD6 CCNA1 CDC42 CDC45 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 TRIM28 ZBTB9
Entrez ID		318	4175
HPRD ID		04168	03485
Ensembl ID		ENSG00000164978	ENSG00000076003
Uniprot IDs		P50583	Q14566
PDB IDs		1XSA 1XSB 1XSC 3U53 4ICK 4IJX	2KLQ 2LE8 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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