HLCS and IFT20

		HLCS	IFT20
Description		holocarboxylase synthetase	intraflagellar transport 20
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix	Golgi Membrane Photoreceptor Outer Segment Golgi Apparatus Cis-Golgi Network Centrosome Centriole Microvillus Cilium Intraciliary Transport Particle B Motile Cilium Photoreceptor Connecting Cilium Stereocilium Dendrite Terminus Ciliary Tip Ciliary Base Kinociliary Basal Body
	Molecular Function	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding	Opsin Binding Protein Binding Small GTPase Binding
	Biological Process	Biotin Metabolic Process Protein Biotinylation Histone Modification Response To Biotin Histone Biotinylation	Establishment Of Planar Polarity Kidney Development Smoothened Signaling Pathway Spermatogenesis Visual Learning Protein Localization To Golgi Apparatus Photoreceptor Cell Outer Segment Organization Opsin Transport Intraciliary Transport Establishment Of Epithelial Cell Apical/basal Polarity Centrosome Localization Cardiac Muscle Cell Differentiation Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Regulation Of Canonical Wnt Signaling Pathway Neural Precursor Cell Proliferation Protein Localization To Cilium Protein Localization To Plasma Membrane Cochlea Development Regulation Of Cilium Assembly Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Autophagosome Assembly
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency	Intraflagellar transport Intraflagellar transport
Drugs		Biotin
Diseases
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)	Osteoprotegerin levels ( 25080503)
Interacting Genes		17 interacting genes: ACACB ANKRD29 BACH1 DDX52 IFNAR2 IFNGR2 IFT20 KRTAP5-9 LANCL2 MED19 NGB POT1 SNX27 SOD1 SPATA46 TGM3 WIPF1	53 interacting genes: ABHD15 ABI2 ABI3 AQP1 BLOC1S6 C1orf216 CCHCR1 CD209 CLEC4M COASY CORO1A CROCCP2 DISC1 DTNBP1 EMILIN1 EXOC7 FAM81B FBF1 FSD2 GOLGA2 HAUS1 HLCS HTT IFT57 KAT5 KDM8 KIF3B KNSTRN KPNA2 KRT13 KXD1 MED30 MIS18A NDC80 NUP54 NUP62 OXNAD1 PBX4 PPP1R11 PSMA1 PTPN12 RAB11FIP4 RALGPS2 RASSF4 RICTOR SH3BP5 SYCE2 TP53I13 TREX1 USHBP1 WASF1 WASHC3 ZDHHC17
Entrez ID		3141	90410
HPRD ID		08360	17137
Ensembl ID		ENSG00000159267	ENSG00000109083
Uniprot IDs		P50747	A0A024QZ08 A0A087X2B4 Q8IY31
PDB IDs
Enriched GO Terms of Interacting Partners?
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