HLA-C and NPSR1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		HLA-C	NPSR1
Description		major histocompatibility complex, class I, C	neuropeptide S receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Recycling Endosome Membrane Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Peptide Antigen Binding TAP Binding	Vasopressin Receptor Activity Neuropeptide Receptor Activity
	Biological Process	Adaptive Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Innate Immune Response	Neuropeptide Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Halothane
Diseases
GWAS		AIDS progression ( 19115949) Albumin-globulin ratio ( 29403010) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 27182965 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 31619474) Asthma and major depressive disorder ( 31619474) Atopic dermatitis ( 23042114 25574825) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 33549134) Basophil count ( 32888494) Beta-2 microglubulin plasma levels ( 23417110) Birth weight ( 31043758) Blood cell traits (multivariate analysis) ( 31080455) Blood protein levels ( 29875488 28240269) Body shape index ( 34021172) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cervical cancer ( 28806749) Chickenpox ( 28928442) Childhood ear infection ( 27182965 28928442) Cholesterol, total ( 26582766) Chronic hepatitis B infection ( 25802187) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cold sores ( 28928442) Complement C3 and C4 levels ( 23028341) Coronary heart disease ( 22319020) Crohn's disease ( 23128233 26891255) Cutaneous psoriasis ( 26626624) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Drug-induced liver injury (flucloxacillin) ( 30661239) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) Feeling hurt ( 29500382) Feeling nervous ( 29500382) Feeling worry ( 29500382) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 25282103 23563607 31562340) Hematuria ( 30476138) Hematuria (mild) ( 30476138) Hematuria (moderate to severe) ( 30476138) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hepatitis B ( 24162738) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 21051598 20041166) HIV-1 susceptibility ( 23935489) HIV-1 viral setpoint ( 26039976) Hypothyroidism ( 22493691) IgE levels ( 24324648) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 28067908) Irritable bowel syndrome ( 33608531) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol ( 26582766) Leprosy ( 32421744) Leukoderma in response to rhododendrol ( 32558222) Lung cancer ( 28604730) Lymphocyte counts ( 32888494 27863252) Major depressive disorder and major depressive episode treated with electroconvulsive therapy ( 33483693) Major depressive episode treated with electroconvulsive therapy ( 33483693) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mean platelet volume ( 32888494) Monocyte count ( 29403010) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Myositis ( 26291516) Nasopharyngeal carcinoma ( 20512145) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil count ( 29403010 32888494 27863252) Nevirapine-induced hypersensitivity in HIV (Stevens-Johnson syndrome or toxic epidermal necrosis) ( 28062682) Non-albumin protein levels ( 29403010) Offspring birth weight ( 31043758) Perceived unattractiveness to mosquitoes ( 28199695) Plantar warts ( 28928442) Pneumonia ( 28928442) Protein quantitative trait loci ( 18464913) Psoriasis ( 30921485 20953188 20953190 23143594 18369459 18364390 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 20953186) Red blood cell count ( 32888494) Response to hepatitis B vaccine ( 29534301) Reticulocyte count ( 27863252) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Self-reported allergy ( 23817569) Serum albumin level ( 29403010) Setpoint viral load in HIV-1 infection ( 26553974) Severity of facial solar lentigines ( 27327535) Shingles ( 28928442) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 25604533) Tonsillectomy ( 27182965 28928442) Triglyceride levels ( 33339817) Tuberculosis ( 28928442) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 28067908) Vitiligo ( 20526339) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 29403010 32888494 27863252 21738480 28158719) White blood cell count (basophil) ( 29403010) White blood cell count (lymphocyte) ( 28158719)	Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Asthma ( 29273806) Leisure-time exercise behaviour ( 30102679) Plasma anti-thyroglobulin levels ( 29678681) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		24 interacting genes: B2M BATF2 CALR CD8A CDC25A GPR182 GPR37 HSPA5 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS2 KIR2DS4 LILRB1 LILRB2 MAPK8IP2 NPSR1 OPRL1 PRRG4 TANK TAP2 TAPBP YBX1	17 interacting genes: ATP5F1A CCT2 ENTPD6 GABARAPL2 HLA-C IPO13 MFSD10 PGM2L1 PMPCA PMPCB PRR36 RABGGTB SLC3A2 SLC41A3 TERF2IP TMED10 TMEM101
Entrez ID		3107	387129
HPRD ID		00829	10547
Ensembl ID		ENSG00000204525	ENSG00000187258
Uniprot IDs		O19617 P10321 Q6R739 Q95HC2	A0A090N8Z1 Q6W5P4
PDB IDs		1EFX 1IM9 1QQD 3BZF 4NT6 5VGD 5VGE 5W67 5W69 5W6A 6JTO 6PA1 6PAG
Enriched GO Terms of Interacting Partners?
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