HLA-B and LILRB1

Number of citations of the paper that reports this interaction (PubMedID 12853576)
142

Data Source:
HPRD (in vitro)

		HLA-B	LILRB1
Description		major histocompatibility complex, class I, B	leukocyte immunoglobulin like receptor B1
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Recycling Endosome Membrane Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Peptide Antigen Binding TAP Binding Chaperone Binding	Amyloid-beta Binding Protein Binding Protein Phosphatase 1 Binding MHC Class Ib Protein Complex Binding MHC Class Ib Protein Binding HLA-A Specific Inhibitory MHC Class I Receptor Activity HLA-B Specific Inhibitory MHC Class I Receptor Activity MHC Class I Receptor Activity MHC Class Ib Receptor Activity Inhibitory MHC Class I Receptor Activity SH2 Domain Binding MHC Class I Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of T Cell Anergy Defense Response Immune Response Detection Of Bacterium Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Protection From Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Regulation Of Dendritic Cell Differentiation	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Adaptive Immune Response T Cell Proliferation Involved In Immune Response Negative Regulation Of Cytokine Production Involved In Immune Response Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Signal Transduction Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Serotonin Secretion Cytokine-mediated Signaling Pathway Receptor Internalization Negative Regulation Of Interferon-beta Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Alpha-beta T Cell Activation Defense Response To Virus Negative Regulation Of Calcium Ion Transport Positive Regulation Of Macrophage Cytokine Production Cellular Response To Lipopolysaccharide Negative Regulation Of Transforming Growth Factor Beta Production Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Negative Regulation Of Dendritic Cell Differentiation Negative Regulation Of Osteoclast Development
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Abacavir N-Formylmethionine Coccidioides immitis spherule
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Acute anterior uveitis in ankylosing spondylitis ( 32492107 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Ankylosing spondylitis ( 21743469 30946743) Anti-thyroid drug induced agranulocytosis ( 27157822) Apolipoprotein A1 levels ( 32203549) Asthma ( 30929738 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738 31619474) Asthma and major depressive disorder ( 31619474) Atopic dermatitis ( 25574825) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Behcet's disease ( 24326010 27548383) Beta-2 microglubulin plasma levels ( 23417110) Blood protein levels ( 29875488 28240269) Body fat percentage variance ( 31453325) Body shape index ( 34021172) Body size at age 10 ( 32376654) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Cardiometabolic and hematological traits ( 27668658) CD4:CD8 lymphocyte ratio ( 20045101) CD8-positive T-lymphocyte count ( 20045101) Cervical cancer ( 23482656 28806749) Change in intraocular pressure in response to steroid treatment (triamcinolone acetonide) ( 25813999) Chickenpox ( 28928442) Clozapine-induced agranulocytosis ( 25187353) Cold sores ( 28928442) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Crohn's disease ( 26891255) Diastolic blood pressure ( 25249183) Diffuse large B cell lymphoma ( 25261932) Drug-induced liver injury (flucloxacillin) ( 19483685 30661239) Eosinophil counts ( 29403010) Eosinophil percentage of white cells ( 27863252) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Estimated glomerular filtration rate in diabetes ( 31451708) Frontal fibrosing alopecia ( 30850646) Gastroesophageal reflux disease ( 31527586) Giant cell arteritis ( 28041642) Graves' disease ( 21841780) HDL cholesterol levels ( 32203549) Height ( 19343178 23563607 31562340) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 21051598 20041166) HIV-1 susceptibility ( 23935489) HIV-1 viral setpoint ( 20205591 26039976) Hypothyroidism ( 22493691) IgA nephropathy ( 26028593) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol levels ( 32203549) Leukoderma in response to rhododendrol ( 32558222) Lung cancer in ever smokers ( 28604730) Malaria ( 31844061) Marginal zone lymphoma ( 25569183) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Medication use (salicylic acid and derivatives) ( 31015401) Metabolic syndrome ( 31589552) Monocyte count ( 29403010) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 22190364 19525953) Myositis ( 26291516) Nasal polyps ( 30643255) Nasopharyngeal carcinoma ( 20512145) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil count ( 29403010) Neutrophil percentage of white cells ( 32888494) Nevirapine-induced hypersensitivity in HIV ( 28062682) Non-albumin protein levels ( 29403010) Penicillin allergy ( 32888428) Peripheral artery disease ( 31285632) Plantar warts ( 28928442) Platelet count ( 22139419 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pneumonia ( 28928442) Pre-treatment viral load in HIV-1 infection ( 31219150) Primary sclerosing cholangitis ( 23603763) Proliferative diabetic retinopathy ( 31482010) Psoriasis ( 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Red blood cell count ( 32888494) Rheumatic heart disease ( 32488134) Rheumatoid arthritis (ACPA-negative) ( 24532677) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Serum albumin level ( 29403010) Setpoint viral load in HIV-1 infection ( 26553974) Severe aplastic anemia ( 32004448) Shingles ( 30298529 25297839 28928442) Small cell lung carcinoma ( 28604730) Strep throat ( 28928442) Sulfasalazine-induced agranulocytosis ( 28762467) Systemic lupus erythematosus ( 26606652 28714469) Systolic blood pressure ( 25249183) Takayasu arteritis ( 33308445 25604533 30498034 23830517) Tonsillectomy ( 28928442) Trichloroethylene-induced hypersensitivity syndrome ( 26190474) Triglyceride levels ( 32203549 33339817) Tuberculosis ( 28928442) Type 2 diabetes ( 25102180) Ulcerative colitis ( 28067908) Visceral adipose tissue adjusted for BMI ( 22589738) Vitiligo ( 20526339) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 25096241 29403010 32888494 21738480) White blood cell count (basophil) ( 27863252) White matter integrity (mean diffusivity) ( 32358547)	Blood protein levels ( 30072576 29875488 28240269) Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		16 interacting genes: ARHGEF4 ATF7IP B2M CD8A CSF1 KIR3DL1 KIR3DS1 KLRD1 LILRB1 LILRB2 MAGEA1 SRC STAT1 TRA TRB TRIB3	6 interacting genes: B2M HLA-A HLA-B HLA-C HLA-F HLA-G
Entrez ID		3106	10859
HPRD ID		00828	07273
Ensembl ID		ENSG00000234745	ENSG00000104972
Uniprot IDs		E5FQ95 P01889	A0A087WSV6 A0A087WSX8 A0A0B4J1W1 A8MVE2 D9IDM5 Q8NHL6
PDB IDs		1A1M 1A1N 1A1O 1A9B 1A9E 1AGB 1AGC 1AGD 1AGE 1AGF 1CG9 1E27 1E28 1HSA 1JGD 1JGE 1K5N 1M05 1M6O 1MI5 1N2R 1OF2 1OGT 1SYS 1SYV 1UXS 1UXW 1W0V 1W0W 1XH3 1XR8 1XR9 1ZHK 1ZHL 1ZSD 2A83 2AK4 2AXF 2AXG 2BSR 2BSS 2BST 2BVO 2BVP 2BVQ 2H6P 2HJL 2NW3 2NX5 2RFX 2YPK 2YPL 3B3I 3B6S 3BP4 3BP7 3BW9 3BWA 3C9N 3CZF 3D18 3DTX 3DX6 3DX7 3DX8 3DXA 3FFC 3HCV 3KPL 3KPM 3KPN 3KPO 3KPP 3KPQ 3KPR 3KPS 3KWW 3KXF 3L3D 3L3G 3L3I 3L3J 3L3K 3LKN 3LKO 3LKP 3LKQ 3LKR 3LKS 3LN4 3LN5 3LV3 3MV7 3MV8 3MV9 3SJV 3SKM 3SKO 3SPV 3UPR 3VCL 3VFS 3VFT 3VFU 3VFV 3VFW 3VH8 3VRI 3VRJ 3W39 3WUW 3X11 3X12 3X13 3X14 4G8G 4G8I 4G9D 4G9F 4JQV 4JQX 4LCY 4LNR 4MJI 4O2C 4O2E 4O2F 4PR5 4PRN 4QRP 4QRQ 4QRR 4QRS 4QRT 4QRU 4U1H 4U1I 4U1J 4U1K 4U1L 4U1M 4U1N 4U1S 4XXC 5B38 5B39 5DEF 5DEG 5EO0 5EO1 5IB1 5IB2 5IB3 5IB4 5IB5 5IEH 5IEK 5IM7 5INC 5IND 5T6W 5T6X 5T6Y 5T6Z 5T70 5TXS 5U98 5V5L 5V5M 5VUD 5VUE 5VUF 5VWD 5VWF 5VWH 5VWJ 5VZ5 5WMN 5WMO 5WMP 5WMQ 5WMR 5XOS 5XOT 6AT5 6AVF 6AVG 6BJ2 6BJ3 6BJ8 6BXP 6BXQ 6D29 6D2B 6D2R 6D2T 6MT3 6MT4 6MT5 6MT6 6MTL 6MTM 6P23 6P27 6P2C 6P2F 6P2S 6PYJ 6PYL 6PYV 6PYW 6PZ5 6VMX 7LFZ 7LG0	1G0X 1P7Q 1UFU 1UGN 1VDG 3D2U 4LL9 4NO0 5KNM 6AEE 6EWA 6EWC 6EWO 6K60 6ZDX
Enriched GO Terms of Interacting Partners?
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