HIP1 and CYRIB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HIP1	CYRIB
Description		huntingtin interacting protein 1	CYFIP related Rac1 interactor B
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Intracellular Membrane-bounded Organelle Presynapse Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse	Extracellular Region Mitochondrion Cilium Membrane Platelet Alpha Granule Lumen Extracellular Exosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Glutamate Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding MHC Class Ib Protein Binding, Via Antigen Binding Groove Small GTPase Binding
	Biological Process	Endocytosis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Protein Kinase B Signaling Clathrin-dependent Endocytosis Apoptotic Signaling Pathway Neurotransmitter Receptor Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Activation Regulation Of Chemotaxis Negative Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Molecule Of Bacterial Origin Regulation Of Mitochondrial Fission Regulation Of Establishment Of Cell Polarity Positive Regulation Of Memory T Cell Activation
Pathways		Clathrin-mediated endocytosis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	Platelet degranulation
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Alcoholism (12-month weekly alcohol consumption) ( 21529783) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 26961502 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Fasting insulin ( 33402679) Interleukin-6 levels ( 22205395) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)
Interacting Genes		37 interacting genes: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CFAP53 CLTA CLTB CLTC CYRIB DAZAP2 DVL2 EHHADH EIF6 FAM168A FBXO25 GLS2 HIP1R HTT IFT57 ITSN1 LITAF LNX1 MAP3K1 MAPK6 NECAP1 PFDN1 RAD23B REL RPRM RPS10 SMURF1 SYT17 TCEA2 TCEANC TFAP2A	3 interacting genes: HIP1 MAPK6 NIF3L1
Entrez ID		3092	51571
HPRD ID		03461	13313
Ensembl ID		ENSG00000127946	ENSG00000153310
Uniprot IDs		B4DK46 O00291	A0A024R9G4 Q9NUQ9
PDB IDs		2NO2 2QA7 3I00	7AJK
Enriched GO Terms of Interacting Partners?
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