GZMK and NPLOC4

Number of citations of the paper that reports this interaction (PubMedID 20876349)
10

Data Source:
BioGRID (enzymatic study)

		GZMK	NPLOC4
Description		granzyme K	NPL4 homolog, ubiquitin recognition factor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Nucleus Nucleoplasm Endoplasmic Reticulum Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	Proteolysis	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway
Pathways			Translesion Synthesis by POLH
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488)	Advanced age-related macular degeneration ( 26691988) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Central corneal thickness ( 32528159) Eye color traits ( 20463881) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myopia ( 27182965) Non-albumin protein levels ( 29403010) Optic disc size ( 31809533) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 27863252 28957414) Refractive astigmatism ( 30306274) Refractive error ( 32231278)
Interacting Genes		13 interacting genes: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TMBIM6 TUBB3 UFD1 VCP	9 interacting genes: CDC42 ERCC6 GZMK MAP3K1 RAF1 UBC UFD1 VCP VPS26B
Entrez ID		3003	55666
HPRD ID		02872	06975
Ensembl ID		ENSG00000113088	ENSG00000182446
Uniprot IDs		P49863	A0A024R8R4 Q8TAT6
PDB IDs		1MZA 1MZD
Enriched GO Terms of Interacting Partners?
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