UBQLN2 and ADAMTS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		UBQLN2	ADAMTS3
Description		ubiquilin 2	ADAM metallopeptidase with thrombospondin type 1 motif 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Autophagosome Cytosol Plasma Membrane Cytoplasmic Vesicle	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Heparin Binding Zinc Ion Binding
	Biological Process	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Ubiquitin-dependent ERAD Pathway Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Autophagosome Assembly	In Utero Embryonic Development Vascular Endothelial Growth Factor Production Protein Processing Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Collagen Biosynthetic Process Supramolecular Fiber Organization Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways		Cargo recognition for clathrin-mediated endocytosis	Collagen biosynthesis and modifying enzymes Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholesterol ester levels in large LDL ( 29084231) Cholesterol ester levels in medium LDL ( 29084231) Cholesterol, total ( 25961943) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Dental caries ( 23259602) Dialysis-related mortality ( 21546767) Glycine levels ( 31070104) Height ( 28552196 20881960 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172 25673412) Hippocampal volume ( 29274321) Hippocampal volume in mild cognitive impairment ( 29274321) Large LDL particle concentration ( 29084231) Medium LDL particle concentration ( 29084231) Metabolite levels ( 22916037) Serum total cholesterol levels ( 29084231) Small LDL particle concentration ( 29084231) Subcortical volume (MOSTest) ( 32665545) Total cholesterol levels in large LDL ( 29084231) Total cholesterol levels in LDL ( 29084231) Total cholesterol levels in medium LDL ( 29084231) Total cholesterol levels in small LDL ( 29084231) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 26785701 28448500)
Interacting Genes		250 interacting genes: - ABI2 ACOT7 ADAMTS3 ADRM1 AGR2 AGR3 AMBN ANKRD33 APOC2 APOC4 ARRDC3 ASCL1 ATP6V1G1 ATXN7 AZGP1 BAG6 BCL2L11 BPIFA1 BTRC C1orf94 C1QA C1QB C1QC C1QL4 C1QTNF2 C1QTNF4 C6orf15 C8G CCDC158 CCK CCL16 CCL3 CCL7 CCN1 CD93 CD99L2 CDH15 CDH17 CDIP1 CDSN CEACAM6 CLEC11A CLPSL2 CNNM3 COL10A1 COL17A1 COL1A2 COL8A1 COL9A2 COLGALT2 CSN1S1 CSN2 CSN3 CST1 CST4 CTAG1A CTAG1B CTDNEP1 DAZAP2 DDR1 DEFA1 DEFA1B DEFA6 DEFB115 DMKN DUSP21 ECM1 ECRG4 EFEMP1 EGFL6 ERP27 ERP29 ETNK1 F10 FAM168A FAM222B FBXO25 FDCSP FGF17 FKBP2 FNDC11 FUCA1 FUS FZD7 GAL GALP GHRL GPR162 GPX7 GUCA2A GUCA2B HEMK1 HERC3 HERPUD1 HNRNPA3 HSD17B12 HSPA13 ICAM1 IFNA13 IGFBP6 IGLL1 IL11 IQCF3 IST1 ITPKB ITPRIPL1 JPH4 KISS1 KLHL11 KLHL42 KRT6A KRTAP12-1 KRTAP13-1 KRTAP19-3 KRTAP19-5 LAIR2 LCN1 LCN2 LITAF LMO4 LY6G6D MBL2 MDK MICOS10-NBL1 MIEF1 MIEF2 MINPP1 MOAP1 MTNR1B MTX2 MYDGF MYO15B NAP1L1 NAXD NBL1 NDOR1 NME3 NOC4L NOL3 NPBWR1 NPPA NPVF NPY NRN1L NT5C3A NUP58 ODAPH OPN4 OR7D4 OSMR PARM1 PCDHGA9 PIANP PIK3IP1 PIN1 PLAAT2 PLAAT3 PLEKHB2 PMEPA1 PNMA3 PODXL POLE2 POM121 PPIB PPIC PPIH PRAP1 PRPF40A PRR4 PSMA2 PSMA5 PSMD4 PSORS1C2 PTGDS QPCT RASSF5 RBFOX2 RBM24 RNF11 RNF128 RNF208 RNF4 RPN1 RSRC2 RTL8A RTL8B RTL8C SCG5 SCGB2B2 SEMG1 SERPINE1 SERPINI2 SEZ6 SEZ6L SFTPA2 SGTA SLC16A3 SLC29A2 SLITRK1 SLPI SMIM11 SMIM19 SMIM2 SMR3B SMURF1 SNRPB SOD3 SPAG11B SPINT1 SPN SRGN SRP68 SUOX SUSD4 TBK1 TENT5B TFF3 TIMM21 TIMP2 TMEM123 TMEM31 TNFRSF18 TOMM20L TXNDC12 TXNDC5 UACA UBA52 UBAC1 UBB UBC UBE2I UBE2V1 UBE3A UBQLN1 UBQLN4 UBXN1 UBXN7 UFSP1 VENTX VIP VTN VWC2 WFDC10B WFDC12 ZFAND2A ZFAND2B ZG16 ZG16B ZNF205	1 interacting genes: UBQLN2
Entrez ID		29978	9508
HPRD ID		02224	06893
Ensembl ID		ENSG00000188021	ENSG00000156140
Uniprot IDs		Q9UHD9	B7Z2U9 O15072 Q96AY5
PDB IDs		1J8C 2NBV 6MUN
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?