SENP1 and HIPK2

Number of citations of the paper that reports this interaction (PubMedID 16253240)
11

Data Source:
BioGRID (enzymatic study)

		SENP1	HIPK2
Description		SUMO specific peptidase 1	homeodomain interacting protein kinase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity SUMO-specific Endopeptidase Activity SUMO-specific Isopeptidase Activity	Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding SMAD Binding Virion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Desumoylation Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Positive Regulation Of Protein Phosphorylation Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Transforming Growth Factor Beta Receptor Signaling Pathway Smoothened Signaling Pathway Adult Walking Behavior Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Retina Layer Formation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Neuron Differentiation Erythrocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway PML Body Organization Positive Regulation Of Protein Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Embryonic Camera-type Eye Morphogenesis Voluntary Musculoskeletal Movement Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Embryonic Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye SMAD Protein Signal Transduction Iris Morphogenesis Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		SUMO is proteolytically processed RHOF GTPase cycle	YAP1- and WWTR1 (TAZ)-stimulated gene expression SUMOylation of transcription cofactors Physiological factors Regulation of TP53 Activity through Phosphorylation RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MECP2 expression and activity
Drugs			Fostamatinib
Diseases
GWAS		Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Macular thickness ( 30535121) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30891314)	Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Systolic blood pressure ( 28135244)
Interacting Genes		25 interacting genes: APP CAV3 GCM1 HDAC1 HIPK1 HIPK2 KCNK1 KEAP1 NACC1 PARP1 PIAS3 PIM1 PML PRIM1 RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28	54 interacting genes: AATF ABL1 BTRC CBX3 CHMP4B CREBBP CUL1 CXCL1 DAXX DDX39A DDX39B FBXW7 H2BC21 HMGA1 KAT2B MAP3K7 MBP MDM2 MECP2 MKNK1 MYB MYBL1 NKX2-1 NKX2-5 NKX3-1 NLK NTRK1 PARP1 PAX6 PML PTCH1 RANBP9 RUNX1 SCAP SENP1 SIAH1 SIAH2 SIRT1 SKI SMAD1 SMAD2 SMAD3 SP100 SUMO1 SUMO2 SUMO3 TP53 TP53INP1 TP63 TP73 TRADD UBE2I WSB1 ZBTB4
Entrez ID		29843	28996
HPRD ID		07153	06039
Ensembl ID		ENSG00000079387	ENSG00000064393
Uniprot IDs		Q6N001 Q7Z3G1 Q9P0U3	Q9H2X6
PDB IDs		2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ	6P5S 7NCF
Enriched GO Terms of Interacting Partners?
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