USP25 and TMEM43

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		USP25	TMEM43
Description		ubiquitin specific peptidase 25	transmembrane protein 43
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol	Integral Component Of Nuclear Inner Membrane Endoplasmic Reticulum Lumen Golgi Apparatus
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Peptidase Activity Ubiquitin-like Protein-specific Protease Activity Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Binding ATPase Binding	Protein Binding Identical Protein Binding Protein Self-association
	Biological Process	Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway	Nuclear Membrane Organization
Pathways		Ub-specific processing proteases
Drugs
Diseases
GWAS		Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Heel bone mineral density ( 30598549) Longevity ( 33657282)
Interacting Genes		22 interacting genes: ACTA1 FBXL17 FLNC GAPDH MAGEB4 MID2 MT2A NGEF PUS10 RAD23A RAD23B SENP1 SKIL SUMO1 SUMO2 SUMO3 SYK TMEM43 TNKS UBC UBE2I ZNF426	16 interacting genes: APOA5 ARL13B CARD10 CISD2 FAM209A FDFT1 FGA FKBP8 GRAMD2B LMNA PCYT1B SCGB1A1 SIAH1 SYNDIG1 USP25 ZCCHC12
Entrez ID		29761	79188
HPRD ID		05296	15541
Ensembl ID		ENSG00000155313	ENSG00000170876
Uniprot IDs		Q9UHP3	A0A024R2F9 Q9BTV4
PDB IDs		2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM
Enriched GO Terms of Interacting Partners?
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