GSTZ1 and PLEKHG4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GSTZ1	PLEKHG4
Description		glutathione S-transferase zeta 1	pleckstrin homology and RhoGEF domain containing G4
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol	Cytosol
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Maleylacetoacetate Isomerase Activity Identical Protein Binding Protein Homodimerization Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	L-phenylalanine Catabolic Process Tyrosine Catabolic Process Glutathione Metabolic Process Cellular Oxidant Detoxification	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Glutathione conjugation Regulation of pyruvate dehydrogenase (PDH) complex Tyrosine catabolism	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		Glutathione 1,4-Dithiothreitol Dichloroacetic acid Glycerin
Diseases
GWAS			Blood protein levels ( 29875488 28240269) Body shape index ( 34021172) Heel bone mineral density ( 28869591) High density lipoprotein cholesterol levels ( 33339817) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		10 interacting genes: CLVS2 GORASP2 GSS PLEKHG4 PPP1CC PSEN1 QARS1 TCP11 TRAF2 ZMYND12	66 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13 FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PLA2G15 PPP1R32 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648
Entrez ID		2954	25894
HPRD ID		04785	10890
Ensembl ID		ENSG00000100577	ENSG00000196155
Uniprot IDs		A0A0A0MR33 A0A0C4DFM0 O43708	A0A024R6X4 Q58EX7
PDB IDs		1FW1
Enriched GO Terms of Interacting Partners?
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